INT30209

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Context Info
Confidence 0.72
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 7.95
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN5A)
Anatomy Link Frequency
blood 2
oocyte 2
SSS 2
embryos 1
substantia nigra 1
SCN5A (Homo sapiens)
SCN5A - R878C (2)
Pain Link Frequency Relevance Heat
sodium channel 24 100.00 Very High Very High Very High
tetrodotoxin 24 100.00 Very High Very High Very High
gABA 10 99.84 Very High Very High Very High
Substantia nigra 11 99.12 Very High Very High Very High
Glutamate 11 97.40 Very High Very High Very High
Dopamine 14 96.88 Very High Very High Very High
Nav1.6 7 95.92 Very High Very High Very High
Ventral tegmentum 1 95.44 Very High Very High Very High
agonist 54 94.56 High High
addiction 5 93.88 High High
Disease Link Frequency Relevance Heat
Dilated Cardiomyopathy 15 100.00 Very High Very High Very High
Depression 65 98.92 Very High Very High Very High
Heart Arrhythmia 27 98.62 Very High Very High Very High
Brain Hemorrhage 2 98.08 Very High Very High Very High
Neurologic Manifestations 2 98.04 Very High Very High Very High
Diabetes Mellitus 102 97.04 Very High Very High Very High
Congenital Anomalies 25 96.82 Very High Very High Very High
Nociception 2 96.48 Very High Very High Very High
Disorder Of Lipid Metabolism 5 96.24 Very High Very High Very High
Anxiety Disorder 33 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SCN5A (Nav1.5) staining was strictly localized in the post-equatorial region of the head.
Localization (localized) of SCN5A in head
1) Confidence 0.72 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.45
On day 2, angiography demonstrated partial recanalization of the SSS and the left TS.
Spec (partial) Localization (recanalization) of SSS in SSS
2) Confidence 0.65 Published 2009 Journal No Shinkei Geka Section Abstract Doc Link 19621780 Disease Relevance 1.20 Pain Relevance 0.15
The interviews were all conducted, transcribed and analyzed by the same person, who had been working as a midwife at the clinic where the participants previously had undergone IVF.
Localization (undergone) of IVF
3) Confidence 0.61 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.06 Pain Relevance 0.03
Follow-up angiography showed partial recanalization of the SSS.
Spec (partial) Localization (recanalization) of SSS in SSS
4) Confidence 0.61 Published 1998 Journal J. Korean Med. Sci. Section Abstract Doc Link 9811193 Disease Relevance 1.21 Pain Relevance 0.16
However, there have been relatively few clinical reports associating Na+ channel abnormalities with DCM, most strikingly observed in 13-year-old proband, and all of these have consistently resulted in loss- rather than gain-of- function.26 Olson et al. localized a form of congenital DCM (CMD1E) characterized by progression toward atrial dilatation, frequently followed by right and, sometimes left ventricular dilatation and dysfunction27 to a heterozygous mutation (3823 G?
Localization (localized) of CMD1E associated with congenital anomalies and dilated cardiomyopathy
5) Confidence 0.59 Published 2008 Journal Europace Section Body Doc Link PMC2573028 Disease Relevance 0.99 Pain Relevance 0.07
Confocal microscopy results are consistent with persistent surface localization of R878C-hNav1.5 channels
Localization (localization) of R878C-hNav1.5 (R878C)
6) Confidence 0.54 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0 Pain Relevance 0.30
The resulting overlays (Fig. 5Ac,Bc) of these confocal images (Fig. 5Aa and b, and Ba and b) confirm an extracellular location of the expressed protein in both WT-hNav1.5 and R878C-hNav1.5-expressing cells.
Localization (location) of R878C-hNav1.5 (R878C)
7) Confidence 0.54 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0 Pain Relevance 0
In contrast, they showed in another study that IVF twins aged two to seven years were more likely to be admitted to a hospital, had more admissions per child, longer hospital stays, as well as more surgical interventions and special needs [49].
Localization (aged) of IVF
8) Confidence 0.53 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2978208 Disease Relevance 0.11 Pain Relevance 0.05
Parameter values were based on data from a large randomised controlled trial in which patients who started their first IVF cycle in the Maastricht University Medical Centre were included.
Localization (cycle) of IVF
9) Confidence 0.53 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2978208 Disease Relevance 0 Pain Relevance 0
Overall, the majority of these studies reported higher use of resources for IVF twins.
Localization (use) of IVF
10) Confidence 0.53 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2978208 Disease Relevance 0.16 Pain Relevance 0.04
SCN11A is localized to human chromosome 3 (3p21-24) close to the other TTX-R sodium channel genes SCN5A and SCN10A.
Localization (localized) of SCN5A associated with sodium channel
11) Confidence 0.52 Published 2002 Journal Mol. Neurobiol. Section Abstract Doc Link 12428758 Disease Relevance 0.19 Pain Relevance 0.31
The retrieved oocytes were incubated for 3-4 h in fertilization medium and then depending upon situation (indication, number of oocytes, and previous fertilization rates) decision for IVF or ICSI was taken.
Localization (decision) of IVF in oocytes
12) Confidence 0.41 Published 2008 Journal Journal of Human Reproductive Sciences Section Body Doc Link PMC2700675 Disease Relevance 0.16 Pain Relevance 0.24
The utilization of IVF was 24.25 L/100 bed-days which is similar to the utilization in the ICU (6).
Localization (utilization) of IVF
13) Confidence 0.35 Published 2009 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2687907 Disease Relevance 0 Pain Relevance 0
Further studies on IVF utilization are required in MTH.
Localization (utilization) of IVF
14) Confidence 0.35 Published 2009 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2687907 Disease Relevance 0 Pain Relevance 0
According to the General Health Questionnaire, depressive symptoms were found in 33 and 43% of females prior to IVF and following IVF, respectively (Lok et al., 2002).
Localization (following) of IVF associated with depression
15) Confidence 0.24 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2517152 Disease Relevance 1.28 Pain Relevance 0.12
There may be multiple sources of ROS in an IVF setting including the oocytes, cumulus cell mass, or spermatozoa used for insemination [153].
Localization (setting) of IVF in spermatozoa
16) Confidence 0.21 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.50 Pain Relevance 0.05
Standard site-specific procedures were used for oocyte retrieval and IVF-ET.
Localization (retrieval) of IVF-ET in oocyte
17) Confidence 0.05 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC270000 Disease Relevance 0 Pain Relevance 0
Agents that can be used as monotherapy or in combination to lower blood glucose and HbA1c include biguanides (metformin), insulin, SUs (glyburide, glipizide, glibenclamide), TZDs (rosiglitazone, pioglitazone), GLP-1 receptor agonists (exenatide, liraglutide), ?
Localization (glucose) of HbA1c in blood associated with agonist
18) Confidence 0.04 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963920 Disease Relevance 0.17 Pain Relevance 0.19
In both intact and lesioned rats, the somatodendritic release was about 60% tetrodotoxin (TTX) dependent.
Localization (release) of tetrodotoxin associated with tetrodotoxin
19) Confidence 0.02 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15198664 Disease Relevance 0 Pain Relevance 1.24
The increased release was Ca2+ dependent and tetrodotoxin (TTX) sensitive.
Localization (release) of tetrodotoxin associated with tetrodotoxin
20) Confidence 0.02 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2859354 Disease Relevance 0 Pain Relevance 0.50

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