INT302118

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.26
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprm1, Ppp1r9b) cell differentiation (Ppp1r9b) nucleoplasm (Ppp1r9b)
cytoplasm (Ppp1r9b) signal transducer activity (Oprm1) signal transduction (Oprm1)
Anatomy Link Frequency
striatum 2
spine 1
Oprm1 (Mus musculus)
Ppp1r9b (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 167 100.00 Very High Very High Very High
mu opioid receptor 54 100.00 Very High Very High Very High
tolerance 6 99.92 Very High Very High Very High
MU agonist 23 98.88 Very High Very High Very High
Morphine 281 98.16 Very High Very High Very High
Analgesic 7 97.36 Very High Very High Very High
opiate 6 94.08 High High
Hippocampus 15 89.04 High High
Glutamate 2 86.76 High High
Nucleus accumbens 6 81.44 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 2 64.96 Quite High
Depression 3 62.56 Quite High
Nociception 80 50.00 Quite Low
Congenital Anomalies 2 45.76 Quite Low
Schizophrenia 8 43.44 Quite Low
Urological Neuroanatomy 2 43.20 Quite Low
Stress 6 14.24 Low Low
Pain 3 12.56 Low Low
Opiate Addiction 10 5.00 Very Low Very Low Very Low
Pheochromocytoma 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinophilin appears to be associated with the mu opioid receptor (MOR) in striatum and modulates MOR both at the signaling and endocytosis levels.
MOR Binding (associated) of Spinophilin in striatum associated with mu opioid receptor
1) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.13 Pain Relevance 1.35
Spinophilin appears to be associated with the mu opioid receptor (MOR) in striatum and modulates MOR both at the signaling and endocytosis levels.
mu opioid receptor Binding (associated) of Spinophilin in striatum associated with mu opioid receptor
2) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.13 Pain Relevance 1.35
In mice, for example, opioid agonist activation of MOR causes a significant increase in the association of MOR with spinophilin, a dendritic spine-enriched scaffold protein [38].
MOR Binding (association) of spinophilin in spine associated with mu agonist and opioid receptor
3) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 0.76

General Comments

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