INT302162

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.07
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CASP8, CASP3) cytoplasm (CASP8, CASP3) cytosol (CASP8, CASP3)
peptidase activity (CASP8, CASP3) nucleolus (CASP8, CASP3) nucleus (CASP8, CASP3)
CASP8 (Homo sapiens)
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 85.48 High High
COX-2 inhibitor 52 17.60 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 174 98.40 Very High Very High Very High
Death 40 97.24 Very High Very High Very High
Stress 15 95.20 Very High Very High Very High
Injury 4 94.48 High High
Necrosis 5 86.68 High High
Cancer 127 86.32 High High
Shock 1 60.28 Quite High
Disease 7 44.52 Quite Low
Autoimmune Disease 1 43.68 Quite Low
Repression 2 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One is the direct activation of caspase-3 by caspase 8, and the other is the activation of caspase-9, also a direct activator of caspase 3, through the mitochondrial pathway.
caspase 8 Positive_regulation (activation) of caspase-3
1) Confidence 0.01 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.58 Pain Relevance 0
Finally, caspase-8 activates caspase-3 in order to trigger the final steps of apoptosis (Figure 4).
caspase-8 Positive_regulation (activates) of caspase-3 associated with apoptosis
2) Confidence 0.01 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.49 Pain Relevance 0.04

General Comments

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