INT302164

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.13 Pain Relevance 0.06

plasma membrane (PTEN, PIK3CD) cell differentiation (PIK3CD) enzyme binding (PTEN) lipid metabolic process (PTEN) cytoplasm (PTEN) cytosol (PTEN)

PTEN (Homo sapiens) PIK3CD (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 52 61.84 medulla 1 14.12 withdrawal 2 8.88 Nerve growth factor 1 8.40 Inflammation 26 5.00 cINOD 17 5.00 cytokine 11 5.00 antagonist 5 5.00 aspirin 4 5.00 Paracetamol 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 151 97.80 Prostate Cancer 8 94.36 Cancer 126 87.36 Osteogenic Sarcomas 2 85.80 Stomach Cancer 5 83.48 Leukemia 9 57.36 Death 27 50.00 Neuroblastoma 2 41.96 Pheochromocytoma 1 13.04 Fever 41 6.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The PI3K pathway is negatively regulated by PTEN (phosphatase and TENsin homolog), which converts PIP3 in PIP2, preventing PKB activation and Bad phosphorylation/sequestration.

PTEN Regulation (regulated) of PI3K

1) Confidence 0.16 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.13 Pain Relevance 0.06

General Comments

This test has worked.