INT302167

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.08
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (PTGER2, EGFR) plasma membrane (PTGER2, EGFR) endosome (EGFR)
cell morphogenesis (EGFR) Golgi apparatus (EGFR) endoplasmic reticulum (EGFR)
PTGER2 (Homo sapiens)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 10 99.04 Very High Very High Very High
COX-2 inhibitor 104 5.00 Very Low Very Low Very Low
Inflammation 52 5.00 Very Low Very Low Very Low
cINOD 34 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 82 100.00 Very High Very High Very High
Colon Cancer 46 91.60 High High
Cancer 252 88.48 High High
Apoptosis 302 82.24 Quite High
Adenocarcinoma 10 77.92 Quite High
Death 54 70.28 Quite High
Familial Adenomatous Polyposis 8 62.60 Quite High
Lymphatic System Cancer 8 52.68 Quite High
Leukemia 18 52.20 Quite High
Hematologic Neoplasms 4 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transactivation of EGFR by PGE2 can lead also to AKT activation, which is a well-known survival pathway [49].
PGE2 Positive_regulation (transactivation) of EGFR associated with fever
1) Confidence 0.10 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.37 Pain Relevance 0.04
Moreover, PGE2 transactivates EGFR by triggering the release of amphiregulin, a well-known EGFR ligand [48].
PGE2 Positive_regulation (transactivates) of EGFR associated with fever
2) Confidence 0.10 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.71 Pain Relevance 0.05

General Comments

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