INT302169

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.51
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2, DYNC1LI1) transport (DYNC1LI1) cytoplasm (DYNC1LI1)
signal transducer activity (PTGER2) mitosis (DYNC1LI1) chromosome (DYNC1LI1)
Anatomy Link Frequency
nerve 1
PTGER2 (Homo sapiens)
DYNC1LI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 2 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
medulla 1 96.88 Very High Very High Very High
COX-2 inhibitor 52 84.56 Quite High
cytokine 11 30.24 Quite Low
Inflammation 26 28.36 Quite Low
cINOD 17 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 151 100.00 Very High Very High Very High
Fever 41 100.00 Very High Very High Very High
Pheochromocytoma 1 98.32 Very High Very High Very High
Cancer 126 93.84 High High
Colon Cancer 23 89.88 High High
Neuroblastoma 2 71.44 Quite High
Death 27 50.00 Quite Low
Prostate Cancer 8 46.12 Quite Low
INFLAMMATION 28 28.36 Quite Low
Leukemia 9 8.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chang et al. reported that PGE2 prevented apoptosis induced by NGF (nerve growth factor) withdrawal by increasing the level of dynein light chain, an inhibitor of neuronal NO synthase in pheochromocytoma of the rat adrenal medulla PC12 cells, thus leading to decreased intracellular NO levels [108].
PGE2 Positive_regulation (increasing) of dynein light chain in nerve associated with medulla, nerve growth factor, apoptosis, fever, withdrawal and pheochromocytoma
1) Confidence 0.02 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.51 Pain Relevance 0.25

General Comments

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