INT302170

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.76
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) signal transducer activity (PTGER2)
PTGER2 (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 104 100.00 Very High Very High Very High
cytokine 22 76.48 Quite High
Inflammation 52 74.60 Quite High
antagonist 10 66.92 Quite High
Nerve growth factor 2 13.28 Low Low
withdrawal 4 11.60 Low Low
cINOD 34 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 302 100.00 Very High Very High Very High
Fever 82 100.00 Very High Very High Very High
Adenocarcinoma 10 99.32 Very High Very High Very High
Colon Cancer 46 98.94 Very High Very High Very High
Death 54 96.20 Very High Very High Very High
Prostate Cancer 16 92.36 High High
Cancer 252 90.92 High High
Familial Adenomatous Polyposis 8 88.52 High High
Lymphatic System Cancer 8 78.60 Quite High
Leukemia 18 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated that PGE2 can upregulate the level of the anti-apoptotic protein Bcl-2 in HCA-7 cells (adenocarcinoma), which produce significant amounts of PGE2.
PGE2 Positive_regulation (upregulate) of Gene_expression (level) of Bcl-2 associated with adenocarcinoma, apoptosis and fever
1) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 2.08 Pain Relevance 0.06
Similar results have been observed in human colorectal cancer cells (HCA-7 cell line which expresses COX-2) where PGE2 was able to inhibit apoptosis induced by SC58125, a selective COX-2 inhibitor, and increase Bcl-2 expression [46].
PGE2 Positive_regulation (increase) of Gene_expression (expression) of Bcl-2 associated with colon cancer, cox-2 inhibitor, apoptosis and fever
2) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.68 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox