INT302171

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.03

plasma membrane (PTGER4, RASGRP1) cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) signal transducer activity (PTGER4)

Anatomy Link Frequency A549 1 PTGER4 (Homo sapiens) RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 5 52.08 COX-2 inhibitor 52 5.00 Inflammation 26 5.00 cINOD 17 5.00 cytokine 11 5.00 aspirin 4 5.00 Paracetamol 3 5.00 Spinal cord 2 5.00 withdrawal 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Adenocarcinoma 5 99.20 Fever 41 98.72 Lung Cancer 7 89.00 Cancer 126 76.72 Metastasis 5 69.60 Apoptosis 151 54.12 Death 27 50.00 Sarcoma 1 40.44 Granuloma 1 39.12 INFLAMMATION 28 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PGE2 increases cell proliferation of A549 cells (adenocarcinoma) and this effect is associated with an activation of Ras pathway via EP4 receptor.

EP4 receptor Positive_regulation (activation) of Ras in A549 associated with adenocarcinoma and fever

1) Confidence 0.01 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.03 Pain Relevance 0.03

General Comments

This test has worked.