INT302229

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Context Info
Confidence 0.21
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.69
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
MG-63 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 83.44 Quite High
Inflammation 26 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 338 100.00 Very High Very High Very High
Osteogenic Sarcomas 2 98.98 Very High Very High Very High
Leukemia 12 92.40 High High
Stomach Cancer 5 87.32 High High
Lymphatic System Cancer 4 75.60 Quite High
Death 43 71.76 Quite High
Cancer 172 63.32 Quite High
Colon Cancer 25 53.92 Quite High
Lung Cancer 9 48.48 Quite Low
Adenocarcinoma 5 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that mitochondrial-mediated apoptosis in HepG2 cells, triggered by DLS, is predominantly associated with down-regulation of the Bcl-2/Bax expression ratio.Fig. 3Western blot analysis of the expression levels of caspase3, caspase9, Bcl-2, Bax, caspase8 and DR5 with the treatment of DLS for 24 h (All the experiments were repeated four times.)Fig. 4Bcl-2, Bax, DR5 protein expression in HepG2 cells (×200). a, c, e Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment without DLS. b, d, f Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment with 25 ?
Negative_regulation (down) of Negative_regulation (regulation) of Bcl-2 associated with apoptosis
1) Confidence 0.21 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.64 Pain Relevance 0
NCTD-induced apoptosis was accompanied by an increase in ROS production, loss of mitochondrial membrane potential and release of cytochrome c(cyto-c) from the mitochondria to the cytosol and down-regulation of anti-apoptotic protein Bcl-2 levels with concurrent up-regulation in pro-apoptotic protein Bax levels.
Negative_regulation (down) of Negative_regulation (regulation) of Bcl-2 associated with apoptosis
2) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2987898 Disease Relevance 0.69 Pain Relevance 0
NCTD-induced apoptosis was accompanied by an increase in ROS production, loss of mitochondrial membrane potential and release of cytochrome c(cyto-c) from the mitochondria to the cytosol and down-regulation of anti-apoptotic protein Bcl-2 levels with concurrent up-regulation in pro-apoptotic protein Bax levels.
Negative_regulation (regulation) of Negative_regulation (down) of Bcl-2 associated with apoptosis
3) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2987898 Disease Relevance 0.69 Pain Relevance 0
Similarly, the sensitivity to cisplatin was increased by celecoxib in a human osteosarcoma cell line (MG-63) and this effect was linked to a down-regulation of anti-apoptotic proteins survivin, Bcl-2, and an inhibition of the survival pathway PI3K/Akt [112].
Negative_regulation (down) of Negative_regulation (regulation) of Bcl-2 in MG-63 associated with apoptosis and osteogenic sarcomas
4) Confidence 0.10 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.66 Pain Relevance 0.04

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