INT302231

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.00
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
A549 1
AREG (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 97.32 Very High Very High Very High
imagery 2 40.40 Quite Low
agonist 30 34.20 Quite Low
COX-2 inhibitor 106 5.00 Very Low Very Low Very Low
Inflammation 87 5.00 Very Low Very Low Very Low
cINOD 36 5.00 Very Low Very Low Very Low
cytokine 27 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
diclofenac 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 82 99.44 Very High Very High Very High
Capsule Opacification 90 96.48 Very High Very High Very High
Adenocarcinoma 10 94.80 High High
Chronic Obstructive Pulmonary Disease 2 94.56 High High
Colon Cancer 46 89.88 High High
Corneal Edema 2 87.48 High High
Cancer 276 86.76 High High
Lung Cancer 14 85.40 High High
Cataract 38 80.64 Quite High
Metastasis 14 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amphiregulin is activated by metalloproteases and can be induced by cAMP activation, and increased levels of amphiregulin expression and release in airways, after activation by human airway trypsin-like protease through PAR2 receptor activation, result in mucus hypersecretion in chronic obstructive airway disease [46].
Localization (release) of amphiregulin associated with chronic obstructive pulmonary disease
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.55 Pain Relevance 0
In this case, PGE2 mediates its effect by the release of amphiregulin, the most abundant ligand in A549 cells [59].
Localization (release) of amphiregulin in A549 associated with fever
2) Confidence 0.20 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.09 Pain Relevance 0.03
Moreover, PGE2 transactivates EGFR by triggering the release of amphiregulin, a well-known EGFR ligand [48].
Localization (release) of amphiregulin associated with fever
3) Confidence 0.20 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.64 Pain Relevance 0.05
In the presence of AR-12, all doses tested were capable of significantly (p<0.01) decreasing pAkt expression in irradiated LEC compared to LEC that received UV irradiation in the absence of AR-12 (Figure 2A,B).
Localization (presence) of AR-12
4) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.24 Pain Relevance 0
Therefore, we believe that the use of AR-12 intraoperatively or by impregnation of an IOL, may be safe and effective in inhibiting PCO.
Localization (use) of AR-12 associated with capsule opacification
5) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.48 Pain Relevance 0

General Comments

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