INT302234

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.07
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
small intestine 2
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 61.80 Quite High
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
Inflammation 28 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 183 98.40 Very High Very High Very High
Fever 48 95.52 Very High Very High Very High
Cancer 131 93.92 High High
Lung Cancer 7 92.64 High High
Sarcoma 1 76.32 Quite High
Stress 12 71.76 Quite High
Death 42 63.04 Quite High
Colon Cancer 23 54.36 Quite High
Adenocarcinoma 5 40.68 Quite Low
Familial Adenomatous Polyposis 4 25.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is not undisputed, because it has also been shown in another study that zinc can increase the expression of Bax, leading to an decreased Bcl-2/Bax ratio and the release of cytochrome-c from mitochondria [101].
Negative_regulation (decreased) of Localization (release) of Bax
1) Confidence 0.24 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.85 Pain Relevance 0
Using HCT-116 cell line as a model to reflect the effect on mouse small intestine, it has been shown that the anti-apoptotic effect of dmPGE2, which is known to bind EP2, was tightly related to AKT phosphorylation through activation of EGFR and leads to an inhibition of Bax translocation in mitochondria, an important step for apoptosis [51].
Negative_regulation (inhibition) of Localization (translocation) of Bax in small intestine associated with apoptosis
2) Confidence 0.20 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.23 Pain Relevance 0.03

General Comments

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