INT302240

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.26
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

AREG (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 97.92 Very High Very High Very High
agonist 28 35.00 Quite Low
Inflammation 61 5.00 Very Low Very Low Very Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 41 99.52 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 2 94.56 High High
Colon Cancer 23 90.48 High High
Cancer 146 87.36 High High
Adenocarcinoma 5 76.80 Quite High
Apoptosis 151 75.00 Quite High
Carcinoma 5 72.28 Quite High
Death 27 69.16 Quite High
Metastasis 9 64.00 Quite High
Familial Adenomatous Polyposis 4 61.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amphiregulin is activated by metalloproteases and can be induced by cAMP activation, and increased levels of amphiregulin expression and release in airways, after activation by human airway trypsin-like protease through PAR2 receptor activation, result in mucus hypersecretion in chronic obstructive airway disease [46].
Positive_regulation (increased) of Localization (release) of amphiregulin associated with chronic obstructive pulmonary disease
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.56 Pain Relevance 0
Moreover, PGE2 transactivates EGFR by triggering the release of amphiregulin, a well-known EGFR ligand [48].
Positive_regulation (triggering) of Localization (release) of amphiregulin associated with fever
2) Confidence 0.12 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.70 Pain Relevance 0.05

General Comments

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