INT302240

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.26 Pain Relevance 0.05

AREG (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 9 97.92 agonist 28 35.00 Inflammation 61 5.00 COX-2 inhibitor 52 5.00 cINOD 17 5.00 cytokine 14 5.00 Arthritis 5 5.00 Inflammatory mediators 4 5.00 aspirin 4 5.00 Inflammatory response 3 5.00

Disease Link Frequency Relevance Heat Fever 41 99.52 Chronic Obstructive Pulmonary Disease 2 94.56 Colon Cancer 23 90.48 Cancer 146 87.36 Adenocarcinoma 5 76.80 Apoptosis 151 75.00 Carcinoma 5 72.28 Death 27 69.16 Metastasis 9 64.00 Familial Adenomatous Polyposis 4 61.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Amphiregulin is activated by metalloproteases and can be induced by cAMP activation, and increased levels of amphiregulin expression and release in airways, after activation by human airway trypsin-like protease through PAR2 receptor activation, result in mucus hypersecretion in chronic obstructive airway disease [46].

Positive_regulation (increased) of Localization (release) of amphiregulin associated with chronic obstructive pulmonary disease

1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.56 Pain Relevance 0

Moreover, PGE2 transactivates EGFR by triggering the release of amphiregulin, a well-known EGFR ligand [48].

Positive_regulation (triggering) of Localization (release) of amphiregulin associated with fever

2) Confidence 0.12 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.70 Pain Relevance 0.05

General Comments

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