INT302261

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.34
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PIK3CD) signal transduction (PIK3CD) plasma membrane (PIK3CD)
Anatomy Link Frequency
MG-63 1
basophils 1
PIK3CD (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 17 98.48 Very High Very High Very High
COX-2 inhibitor 52 74.92 Quite High
Inflammation 33 33.12 Quite Low
medulla 1 27.20 Quite Low
withdrawal 4 21.96 Low Low
Nerve growth factor 1 21.48 Low Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 34 99.58 Very High Very High Very High
Osteogenic Sarcomas 2 99.44 Very High Very High Very High
Cancer 455 99.36 Very High Very High Very High
Apoptosis 167 99.12 Very High Very High Very High
Disease 31 98.76 Very High Very High Very High
Stomach Cancer 5 96.56 Very High Very High Very High
Hyperplasia 3 92.20 High High
Prostate Cancer 8 89.36 High High
Metastasis 51 87.44 High High
Fibrosarcoma 8 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cancer recurrence exhibited strong up-regulation of transcripts from genes in both the MAPK/ERK and PI3K/AKT pathways (Figure 2b).
Regulation (regulation) of PI3K associated with cancer and recurrence
1) Confidence 0.29 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 1.57 Pain Relevance 0
These changes mitigate the effect of PTEN loss on the PI3K/AKT pathway and suggest that the loss of PTEN serves primarily to further activate the RET pathway to drive tumor growth.
Regulation (effect) of PI3K associated with cancer
2) Confidence 0.29 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.86 Pain Relevance 0
Taken together, these data suggest that the mechanisms of resistance to the RET targeting selective kinase inhibitors sunitinib and sorafenib are the up-regulation of the targeted MAPK/ERK pathway and the parallel PI3K/AKT pathway.
Regulation (regulation) of PI3K
3) Confidence 0.29 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 1.27 Pain Relevance 0
Further experiments will also be needed to determine if PDCD10 functions in concert with OSM and Krit1 in signaling the regulation of RhoA and PI3K.


Regulation (regulation) of PI3K
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
Celecoxib triggered also apoptosis in osteosarcoma cells (MG-63) through down-regulation of Bcl-2, survivin and PI3K (phosphoinositide 3-kinase) pathway [112].
Regulation (regulation) of PI3K in MG-63 associated with osteogenic sarcomas and apoptosis
5) Confidence 0.19 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.23 Pain Relevance 0.10
These results rule out a possible role of protein kinase C in the complex response of basophil to quercetin, while indirectly suggest PI3K as the major intracellular target of this compound also in human basophils.



Regulation (target) of PI3K in basophils associated with kinase c
6) Confidence 0.17 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.05
Our data also suggested that PI3K is an intracellular target of PO to for achieving its inhibition on angiogenesis.


Regulation (target) of PI3K
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.41 Pain Relevance 0

General Comments

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