INT302272

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.09
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CDK2) nucleoplasm (CDK2) cytoplasm (CDK2)
cytosol (CDK2) mitosis (CDK2) nucleus (CDK2)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 19 61.84 Quite High
COX-2 inhibitor 52 60.16 Quite High
antagonist 5 6.68 Low Low
Inflammation 26 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 52 89.36 High High
Apoptosis 169 88.60 High High
Cancer 196 87.20 High High
Hyperplasia 4 80.68 Quite High
Retinoblastoma 4 71.08 Quite High
Colon Cancer 27 59.28 Quite High
Death 27 50.00 Quite Low
Leukemia 11 16.32 Low Low
Fever 41 5.00 Very Low Very Low Very Low
INFLAMMATION 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, 14-3-3 protein, a transcriptional target of p53, leads to a sequestration of cdk2 in the cytoplasm [83].
Localization (sequestration) of cdk2
1) Confidence 0.30 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.41 Pain Relevance 0.09
However, we were unable to find any translocation difference of Cdk2 with the treatments as observed by [43].
Localization (translocation) of Cdk2
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.13 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Localization (localization) of Cdk2
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.56 Pain Relevance 0

General Comments

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