INT302311

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH, SOST) extracellular region (PTH, SOST) transcription factor binding (SOST)
cell-cell signaling (PTH)
Anatomy Link Frequency
osteocyte 2
PTH (Homo sapiens)
SOST (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 7 34.88 Quite Low
spinal stenosis 1 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 1 5.00 Very Low Very Low Very Low
Sciatica 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 16 100.00 Very High Very High Very High
Postmenopausal Osteoporosis 1 94.56 High High
Hematoma 1 62.88 Quite High
Pressure And Volume Under Development 2 62.32 Quite High
Hypercalcemia 6 61.92 Quite High
Dysphagia 1 50.12 Quite High
Osteolysis 1 44.44 Quite Low
Fracture Healing 6 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTH increases bone formation through several actions, including increasing commitment of mesenchymal stem cells to the osteoblast lineage, increasing osteoblast maturation and possibly life span, and reducing the osteocyte production of sclerostin to further stimulate bone formation.
PTH Negative_regulation (reducing) of Gene_expression (production) of sclerostin in osteocyte associated with osteoporosis
1) Confidence 0.29 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.59 Pain Relevance 0

General Comments

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