INT302312

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)
Anatomy Link Frequency
crest 1
Bmpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 34.04 Quite Low
Central nervous system 1 22.96 Low Low
Spinal cord 2 21.60 Low Low
fibrosis 6 17.72 Low Low
spinal stenosis 1 15.44 Low Low
Sciatica 1 14.68 Low Low
carpal tunnel syndrome 1 11.60 Low Low
transdermal 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heterotopic Ossification 87 65.60 Quite High
Fracture Healing 6 61.20 Quite High
Osteolysis 1 61.12 Quite High
Sarcoma 1 60.40 Quite High
Injury 17 58.12 Quite High
Dysphagia 1 49.68 Quite Low
Tibial Fractures 1 44.20 Quite Low
Pressure And Volume Under Development 4 43.12 Quite Low
Hypoxia 1 35.72 Quite Low
Hypercalcemia 7 35.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant human BMP-2 (rhBMP-2) (Medtronic Australasia, North Ryde, NSW, Australia) was solubilized in sterile water at stock concentrations of 100 ?
Localization (solubilized) of BMP-2
1) Confidence 0.46 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Recombinant human BMP-2 (rhBMP-2) (Medtronic Australasia, North Ryde, NSW, Australia) was solubilized in sterile water at stock concentrations of 100 ?
Localization (solubilized) of rhBMP-2
2) Confidence 0.40 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
In posterolateral lumbar fusion, the use of BMP-2 was compared with iliac crest bone graft and showed a significantly higher fusion rate compared with control subjects [19].
Localization (use) of BMP-2 in crest
3) Confidence 0.11 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.24 Pain Relevance 0
Many modifications/variations of this method have been used in different species under different conditions, including introduction of a DNA construct that produces BMPs [40], microbubble-enhanced transcutaneous sonoporation of human BMP2 [70], nanogel-cross-linking hydrogel as a scaffold [41], implantation of a slow-release system of polylactic acid and rhBMP-2, or sintered porous-surfaced Ti-6Al-4V implants coated with native BMPs [71].
Localization (release) of rhBMP-2
4) Confidence 0.06 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 0.23 Pain Relevance 0

General Comments

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