INT302314

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.22
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SOST) extracellular region (SOST) transcription factor binding (SOST)
Anatomy Link Frequency
hip 1
SOST (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.36 Very High Very High Very High
spinal stenosis 3 98.64 Very High Very High Very High
Sciatica 3 97.88 Very High Very High Very High
carpal tunnel syndrome 3 94.80 High High
fibrosis 110 23.84 Low Low
transdermal 22 5.00 Very Low Very Low Very Low
cva 11 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Stenosis 3 98.64 Very High Very High Very High
Osteoporosis 142 98.26 Very High Very High Very High
Nerve Root Compression 3 97.88 Very High Very High Very High
Targeted Disruption 7 95.52 Very High Very High Very High
Carpal Tunnel Syndrome 6 94.80 High High
Frailty 3 93.88 High High
Apoptosis 3 88.48 High High
Hypercalcemia 51 83.44 Quite High
Fracture Healing 19 79.28 Quite High
Postmenopausal Osteoporosis 17 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, inhibition of sclerostin also results in significant bone formation at the periosteal surface.
Negative_regulation (inhibition) of sclerostin
1) Confidence 0.44 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.28 Pain Relevance 0
The molecular mechanisms underlying these anabolic effects are still poorly understood, but appear to include both direct actions on osteoblastic cells as well as indirect effects such as through stimulation of IGF-1 production and downregulation of sclerostin, a physiologic antagonist of the important anabolic Wnt-?
Negative_regulation (downregulation) of sclerostin associated with antagonist and osteoporosis
2) Confidence 0.42 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.61 Pain Relevance 0.05
Preclinical studies with a sclerostin inhibitor appear to be somewhat different from those with hPTH (1–34).
Negative_regulation (inhibitor) of sclerostin
3) Confidence 0.32 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.12 Pain Relevance 0
In summary, treatments based on inhibition of sclerostin may be a powerful way to restore bone strength of the osteoporotic skeleton in our patients and potentially to provide more efficacious protection from hip fracture than current therapies.


Negative_regulation (inhibition) of sclerostin in hip associated with frailty
4) Confidence 0.32 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 1.01 Pain Relevance 0.24
A deficiency of sclerostin results in increased Wnt signaling and high bone mass.
Negative_regulation (deficiency) of sclerostin
5) Confidence 0.07 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.21 Pain Relevance 0.04

General Comments

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