INT302315

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SOST) extracellular region (SOST) transcription factor binding (SOST)
Anatomy Link Frequency
osteocytes 1
kidney 1
SOST (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 14 5.00 Very Low Very Low Very Low
spinal stenosis 2 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
Sciatica 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 58.24 Quite High
Osteoporosis 32 5.00 Very Low Very Low Very Low
Hypercalcemia 12 5.00 Very Low Very Low Very Low
Fracture Healing 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Carpal Tunnel Syndrome 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Postmenopausal Osteoporosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sclerostin, a glycoprotein secreted by osteocytes and to a lesser extent other cell types (vascular, kidney), is a potent inhibitor of osteoblastogenesis.
Localization (secreted) of Sclerostin in kidney
1) Confidence 0.61 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0 Pain Relevance 0
Sclerostin is secreted from osteocytes and travels through the canaliculi to the bone surface where it binds to coreceptors LRP5 and LRP6 and prevents colocalization with frizzled protein and Wnt signaling, thereby reducing osteoblastogenesis and bone formation [3].
Localization (secreted) of Sclerostin in osteocytes
2) Confidence 0.53 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.11 Pain Relevance 0

General Comments

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