INT302317

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.58
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SOST) extracellular region (SOST) transcription factor binding (SOST)
Anatomy Link Frequency
skeleton 2
SOST (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.36 Very High Very High Very High
fibrosis 110 31.76 Quite Low
carpal tunnel syndrome 2 14.88 Low Low
Sciatica 2 8.00 Low Low
spinal stenosis 2 6.64 Low Low
cva 11 5.00 Very Low Very Low Very Low
transdermal 8 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.78 Very High Very High Very High
Osteoporosis 116 98.98 Very High Very High Very High
Disease 8 98.32 Very High Very High Very High
Hypercalcemia 43 98.04 Very High Very High Very High
Apoptosis 3 89.92 High High
Postmenopausal Osteoporosis 15 71.76 Quite High
Fracture Healing 12 41.36 Quite Low
Cystic Fibrosis 110 31.76 Quite Low
Carpal Tunnel Syndrome 4 17.04 Low Low
Nerve Root Compression 2 8.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A deletion downstream of the SOST gene, which results in reduced sclerostin expression, is associated with a milder form of the disease called van Buchem disease [5].
Positive_regulation (results) of Gene_expression (expression) of sclerostin associated with disease
1) Confidence 0.60 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.20 Pain Relevance 0
The molecular mechanisms underlying these anabolic effects are still poorly understood, but appear to include both direct actions on osteoblastic cells as well as indirect effects such as through stimulation of IGF-1 production and downregulation of sclerostin, a physiologic antagonist of the important anabolic Wnt-?
Positive_regulation (stimulation) of Gene_expression (production) of sclerostin associated with antagonist and osteoporosis
2) Confidence 0.49 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.62 Pain Relevance 0.05
Also, studies find the increases in bone formation induced by antisclerostin antibody, unlike PTH, not associated with increases in bone resorption in the aged rodent skeleton.
Positive_regulation (induced) of Gene_expression (antibody) of sclerostin in skeleton associated with hypercalcemia
3) Confidence 0.49 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.56 Pain Relevance 0
Transgenic mice that overexpress sclerostin are seen to have low bone mass and increased susceptibility to fractures [99] while mice deficient in sclerostin show increased bone density [100].
Positive_regulation (overexpress) of Gene_expression (overexpress) of sclerostin associated with targeted disruption
4) Confidence 0.11 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.20 Pain Relevance 0.03

General Comments

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