INT302318

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SOST) extracellular region (SOST) transcription factor binding (SOST)
SOST (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 88.44 High High
fibrosis 110 5.00 Very Low Very Low Very Low
transdermal 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 1 5.00 Very Low Very Low Very Low
Sciatica 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 5 91.80 High High
Hypercalcemia 17 74.52 Quite High
Targeted Disruption 3 65.04 Quite High
Osteoporosis 30 63.96 Quite High
Bone Cancer 25 5.28 Low Low
Cystic Fibrosis 110 5.00 Very Low Very Low Very Low
Pulmonary Disease 8 5.00 Very Low Very Low Very Low
Fracture Healing 7 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The development of a monoclonal antibody to sclerostin that can be administered subcutaneously has allowed scientists to evaluate the effect of sclerostin blockade on bone metabolism and bone mass.
Regulation (effect) of sclerostin
1) Confidence 0.34 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.18 Pain Relevance 0
Modulation of the Wnt Signaling Pathway

Antisclerostin AntibodyA large family of extracellular glycoproteins, called Wnt proteins, are key regulators of bone remodeling and other cellular processes [95–97].

Regulation (Modulation) of sclerostin
2) Confidence 0.26 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.27 Pain Relevance 0.04

General Comments

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