INT302319

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SOST) mitochondrion (Lrp5) extracellular region (SOST)
endoplasmic reticulum (Lrp5) plasma membrane (Lrp5) transcription factor binding (SOST)
Lrp5 (Mus musculus)
SOST (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 14 5.00 Very Low Very Low Very Low
spinal stenosis 2 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
Sciatica 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 66.52 Quite High
Hypercalcemia 12 27.84 Quite Low
Osteoporosis 32 20.48 Low Low
Targeted Disruption 4 11.92 Low Low
Fracture Healing 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Carpal Tunnel Syndrome 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Postmenopausal Osteoporosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sclerostin (SOST) is thought to function as a paracrine inhibitor of canonical Wnt signaling on the preosteoblast surface by binding to the Wnt coreceptors LRP5 and LRP6 and blocking their colocalization with the frizzled receptor [8].
LRP5 Binding (binding) of SOST
1) Confidence 0.18 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.13 Pain Relevance 0
Sclerostin (SOST) is thought to function as a paracrine inhibitor of canonical Wnt signaling on the preosteoblast surface by binding to the Wnt coreceptors LRP5 and LRP6 and blocking their colocalization with the frizzled receptor [8].
LRP5 Binding (binding) of Sclerostin
2) Confidence 0.18 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.13 Pain Relevance 0

General Comments

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