INT302323

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SOST) extracellular region (SOST) plasma membrane (Wnt2)
molecular_function (Wnt2) transcription factor binding (SOST) cell-cell signaling (Wnt2)
SOST (Homo sapiens)
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
transdermal 14 5.00 Very Low Very Low Very Low
spinal stenosis 2 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
Sciatica 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 66.52 Quite High
Hypercalcemia 12 26.48 Quite Low
Osteoporosis 32 19.12 Low Low
Targeted Disruption 4 10.56 Low Low
Fracture Healing 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Carpal Tunnel Syndrome 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Postmenopausal Osteoporosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sclerostin (SOST) is thought to function as a paracrine inhibitor of canonical Wnt signaling on the preosteoblast surface by binding to the Wnt coreceptors LRP5 and LRP6 and blocking their colocalization with the frizzled receptor [8].
Sclerostin Binding (binding) of Wnt
1) Confidence 0.02 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.13 Pain Relevance 0
Sclerostin (SOST) is thought to function as a paracrine inhibitor of canonical Wnt signaling on the preosteoblast surface by binding to the Wnt coreceptors LRP5 and LRP6 and blocking their colocalization with the frizzled receptor [8].
SOST Binding (binding) of Wnt
2) Confidence 0.02 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.13 Pain Relevance 0

General Comments

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