INT302357

Context Info Confidence 0.33 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.39

cell differentiation (Dlx1) nucleus (Dlx1) DNA binding (Dlx1)

Anatomy Link Frequency brain 1 Dlx1 (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 23 100.00 gABA 10 83.28 Dopamine 1 11.24 Enkephalin 1 9.56 interneuron 5 5.00 Thalamus 4 5.00 Hippocampus 4 5.00 cerebral cortex 3 5.00 Neurotransmitter 2 5.00 Pyramidal cell 2 5.00

Disease Link Frequency Relevance Heat Epilepsy 14 5.00 Intellectual Impairment 14 5.00 Lissencephaly 10 5.00 Syndrome 10 5.00 Congenital Anomalies 9 5.00 Convulsion 8 5.00 Infantile Spasms 7 5.00 Targeted Disruption 7 5.00 Repression 5 5.00 Encephalopathy 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, Dlx2 electroporation in Arx-deficient brain slices induces GAD65 expression, suggesting that Arx is necessary to promote Dlx-dependent GABAergic cell migration, but is dispensable for Dlx ability to induce GABAergic cell fate commitment (Colasante et al., 2008).

Dlx-dependent Binding (migration) of in brain associated with gabaergic

1) Confidence 0.33 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0 Pain Relevance 0.39

General Comments

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