INT30236

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Context Info
Confidence 0.15
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.03
Pain Relevance 11.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Hps4) cytoplasmic membrane-bounded vesicle (Hps4) lysosome (Hps4)
cytoplasm (Hps4)
Anatomy Link Frequency
substantia nigra 1
brain 1
posterior pituitary 1
Hps4 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 87 100.00 Very High Very High Very High
Dynorphin 50 100.00 Very High Very High Very High
Cholecystokinin 9 100.00 Very High Very High Very High
nMDA receptor antagonist 1 99.96 Very High Very High Very High
narcan 25 99.84 Very High Very High Very High
Deafferentation 2 99.46 Very High Very High Very High
opioid receptor 42 99.08 Very High Very High Very High
Substantia nigra 8 98.68 Very High Very High Very High
antagonist 10 98.44 Very High Very High Very High
Dorsal horn 5 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 2 94.08 High High
Hyperalgesia 4 75.76 Quite High
Pain 16 75.00 Quite High
INFLAMMATION 4 75.00 Quite High
Aging 2 75.00 Quite High
Targeted Disruption 3 71.12 Quite High
Pressure And Volume Under Development 2 62.28 Quite High
Hypertrophy 1 50.08 Quite High
Nociception 5 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MK801, an NMDA receptor antagonist, eliminated the antianalgesia from dynorphin A(1-17), cholecystokinin-8s, and LE.
Negative_regulation (eliminated) of LE associated with nmda receptor antagonist, dynorphin, enkephalin and cholecystokinin
1) Confidence 0.15 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303046 Disease Relevance 0 Pain Relevance 2.57
The selective action of Bestatin might indicate the regional differences of ME catabolism in the brain and also differences in the contribution of APN to the inactivation of ME and LE.
Negative_regulation (inactivation) of LE in brain
2) Confidence 0.09 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.24 Pain Relevance 0.43
These effects of LE on ICa were abolished by Naloxone (NAL), an opioid receptor antagonist.
Negative_regulation (abolished) of LE associated with antagonist, narcan, opioid receptor and enkephalin
3) Confidence 0.02 Published 1993 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 8411192 Disease Relevance 0 Pain Relevance 1.27
Furthermore, levels of ir-met-enkephalin (ME) and ir-leu-enkephalin (LE) were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of LE associated with enkephalin
4) Confidence 0.02 Published 1988 Journal Pain Section Abstract Doc Link 2906425 Disease Relevance 0.47 Pain Relevance 1.50
It is concluded that the acute administration of NE + EE2, in general, reduces the levels of ME, LE, DYN and beta-EI.
Negative_regulation (reduces) of LE associated with dynorphin and enkephalin
5) Confidence 0.02 Published 1985 Journal Peptides Section Abstract Doc Link 2866495 Disease Relevance 0 Pain Relevance 1.37
Likewise, in the posterior pituitary, osmotic stimulus (e.g., 2% NaCl as drinking fluid) causes marked depletion in dynorphin and LE but has no effect on ME levels suggesting that in the posterior pituitary LE is derived primarily from dynorphin.
Negative_regulation (depletion) of LE in posterior pituitary associated with dynorphin and enkephalin
6) Confidence 0.02 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860603 Disease Relevance 0.09 Pain Relevance 1.38
Globus pallidus deafferentation resulted in a significant decrease of dynorphin B and LE, but not ME-Arg-Gly-Leu, in the substantia nigra.
Negative_regulation (decrease) of LE in substantia nigra associated with dynorphin, substantia nigra, enkephalin and deafferentation
7) Confidence 0.02 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860603 Disease Relevance 0.09 Pain Relevance 1.42
No decline in LV ME and LE was observed in the 6-hydroxydopamine treated animals.
Neg (No) Negative_regulation (decline) of LE associated with enkephalin
8) Confidence 0.01 Published 1994 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 8089851 Disease Relevance 0.14 Pain Relevance 1.46

General Comments

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