INT302367

Context Info Confidence 0.59 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0.22

cell differentiation (Dlx2, Arx) nucleus (Dlx2, Arx) DNA binding (Dlx2, Arx)

Dlx2 (Mus musculus) Arx (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 23 98.16 amygdala 1 88.60 Thalamus 4 83.52 gABA 10 78.84 cerebral cortex 3 42.32 Hippocampus 4 40.72 interneuron 5 5.00 Neurotransmitter 2 5.00 Pyramidal cell 2 5.00 hyperexcitability 1 5.00

Disease Link Frequency Relevance Heat Convulsion 8 93.56 Targeted Disruption 7 73.92 Epilepsy 14 5.00 Intellectual Impairment 14 5.00 Lissencephaly 10 5.00 Syndrome 10 5.00 Congenital Anomalies 9 5.00 Infantile Spasms 7 5.00 Repression 5 5.00 Encephalopathy 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Consistent with these results, Arx expression was shown to be regulated by several members of the Dlx (Distal-less) family of homeobox proteins, particularly Dlx2 (Cobos et al., 2005; Colasante et al., 2008).

Dlx2 Regulation (regulated) of Gene_expression (expression) of Arx

1) Confidence 0.59 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0.23 Pain Relevance 0.22

General Comments

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