INT302368

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Arx, Pafah1b1) nucleus (Arx, Pafah1b1) transport (Pafah1b1)
nuclear envelope (Pafah1b1) DNA binding (Arx) cytoplasm (Pafah1b1)
Anatomy Link Frequency
brain 1
Arx (Mus musculus)
Pafah1b1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 23 50.00 Quite Low
gABA 10 5.00 Very Low Very Low Very Low
interneuron 5 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Disease 2 99.98 Very High Very High Very High
Lissencephaly 10 98.64 Very High Very High Very High
Intellectual Impairment 14 92.28 High High
Congenital Anomalies 9 88.72 High High
Epilepsy 14 69.88 Quite High
Holoprosencephaly 1 48.16 Quite Low
Autism 1 40.68 Quite Low
Apoptosis 1 24.96 Low Low
Adhesions 1 22.72 Low Low
Syndrome 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lissencephaly, which represents the other end of the spectrum of brain disorders associated with ARX mutations, is also a heterogeneous group of cortical malformations resulting from mutations in at least five different genes: LIS1, DCX (doublecortin), RELN (reelin), ARX and TUBA1A (tubulin alpha1A) (Reiner et al., 1993; des Portes et al., 1998; Gleeson et al., 1998; Hong et al., 2000; Kitamura et al., 2002; Keays et al., 2007).
ARX Binding (associated) of LIS1 in brain associated with brain disease and lissencephaly
1) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 1.25 Pain Relevance 0

General Comments

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