INT30238

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Context Info
Confidence 0.66
First Reported 1985
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 2.77
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Anpep) peptidase activity (Anpep)
Anatomy Link Frequency
microglia 2
caudate-putamen 1
brain 1
olfactory tubercle 1
hippocampus 1
Anpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 15 99.50 Very High Very High Very High
Enkephalin 18 99.40 Very High Very High Very High
anesthesia 11 98.52 Very High Very High Very High
Hippocampus 2 97.80 Very High Very High Very High
Pain 34 92.48 High High
agonist 2 89.08 High High
Dopamine 4 88.76 High High
Neuropeptide 16 83.36 Quite High
Opioid 2 80.96 Quite High
dopamine receptor 2 79.52 Quite High
Disease Link Frequency Relevance Heat
Gallstones 6 99.84 Very High Very High Very High
Urological Neuroanatomy 10 99.36 Very High Very High Very High
Pain 34 92.48 High High
Alagille Syndrome 2 87.60 High High
Mental Disorders 28 86.96 High High
Liver Disease 4 86.84 High High
Athletic Injuries 2 45.16 Quite Low
Disease 8 24.72 Low Low
Knee Injuries 2 21.36 Low Low
Frailty 8 20.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity of aminopeptidase N was upregulated by culture of microglia on astrocytes and down-regulated by exposure of microglia to lipopolysaccharide.
Positive_regulation (upregulated) of aminopeptidase N in microglia
1) Confidence 0.66 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534337 Disease Relevance 0 Pain Relevance 0.28
In contrast, subchronic administration of apomorphine increased aminopeptidase N activity in the frontal cortex and caudate-putamen.
Positive_regulation (increased) of aminopeptidase N in frontal cortex associated with urological neuroanatomy
2) Confidence 0.54 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8613907 Disease Relevance 0.35 Pain Relevance 0.17
Because the two brain aminopeptidases were both sensitive to bestatin, it remains to be established whether both or only aminopeptidase M is involved in endogenous enkephalin inactivation.
Spec (whether) Positive_regulation (involved) of aminopeptidase M in brain associated with enkephalin
3) Confidence 0.48 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860607 Disease Relevance 0 Pain Relevance 0.10
The occurrence of aminopeptidase N on microglia is in line with the view that they originate from the monocytic lineage.
Positive_regulation (occurrence) of aminopeptidase N in microglia
4) Confidence 0.48 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534337 Disease Relevance 0 Pain Relevance 0.27
APN mRNA levels, semi-quantified by RT-PCR, were decreased at stage II and increased at stage V, in frontal cortex-olfactory tubercle, and hippocampus.
Positive_regulation (increased) of APN in olfactory tubercle associated with urological neuroanatomy and hippocampus
5) Confidence 0.40 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17952634 Disease Relevance 0.10 Pain Relevance 0.28
In contrast, subchronic administration of apomorphine increased aminopeptidase N activity in the frontal cortex and caudate-putamen.
Positive_regulation (increased) of aminopeptidase N in caudate-putamen associated with urological neuroanatomy
6) Confidence 0.18 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8613907 Disease Relevance 0.35 Pain Relevance 0.17
Thus, if one considers kcat/Km as the relevant kinetic constant for estimating in vivo peptide hydrolysis, these results are consistent with the involvement of aminopeptidase M and the puromycin-sensitive aminopeptidase in the degradation of extended dynorphin-related peptides.
Positive_regulation (involvement) of aminopeptidase M associated with dynorphin
7) Confidence 0.17 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790884 Disease Relevance 0 Pain Relevance 0.27
In contrast, the serum aminopeptidase-M activity is highly increased in cholestasis.
Positive_regulation (increased) of serum aminopeptidase-M associated with gallstones
8) Confidence 0.16 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12184528 Disease Relevance 0.52 Pain Relevance 0.16
The increase in urinary alanine aminopeptidase excretion associated with enflurane anesthesia is increased further by aminoglycosides.
Positive_regulation (increase) of alanine aminopeptidase associated with anesthesia
9) Confidence 0.15 Published 1988 Journal Anesth. Analg. Section Title Doc Link 2899408 Disease Relevance 0 Pain Relevance 0.26
APN mRNA levels, semi-quantified by RT-PCR, were decreased at stage II and increased at stage V, in frontal cortex-olfactory tubercle, and hippocampus.
Positive_regulation (increased) of APN in hippocampus associated with urological neuroanatomy and hippocampus
10) Confidence 0.13 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17952634 Disease Relevance 0.10 Pain Relevance 0.28
In contrast, the serum aminopeptidase-M activity is highly increased in cholestasis.
Positive_regulation (increased) of serum aminopeptidase-M associated with gallstones
11) Confidence 0.12 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12184528 Disease Relevance 0.52 Pain Relevance 0.16
The degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M was examined using these peptides as alternate substrate inhibitors.
Positive_regulation (puromycin-sensitive) of aminopeptidase M associated with dynorphin
12) Confidence 0.08 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790884 Disease Relevance 0 Pain Relevance 0.25
Degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M.
Positive_regulation (puromycin-sensitive) of aminopeptidase M associated with dynorphin
13) Confidence 0.08 Published 1995 Journal J. Neurochem. Section Title Doc Link 7790884 Disease Relevance 0 Pain Relevance 0.30
Postanesthesia BUN and serum creatinine concentrations decreased, creatinine clearance increased, and urinary N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase excretion increased in all groups compared with preanesthesia values, but there were no significant differences between the low-flow sevoflurane, high-flow sevoflurane, and low-flow isoflurane groups for any renal function parameter at any time after anesthesia.
Positive_regulation (increased) of alanine aminopeptidase
14) Confidence 0.07 Published 1997 Journal Anesthesiology Section Body Doc Link 9197291 Disease Relevance 0 Pain Relevance 0
Generally, the magnitude of changes in SF-36 was similar for patients in THR, TKR, and ACL groups, with smaller changes in the APM group.
Positive_regulation (changes) of APM
15) Confidence 0.04 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0.58 Pain Relevance 0.31
Our results also indicate that overall, patients who underwent THR, TKR, APM, and ACL reconstruction surgery showed improvements in the health domains assessed by the SF-36 subscales.
Positive_regulation (underwent) of APM
16) Confidence 0.04 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0.26 Pain Relevance 0.13

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