INT302425

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Anatomy Link Frequency
nucleus 1
cortex 1
Rtn4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 36 99.90 Very High Very High Very High
corticosteroid 196 98.38 Very High Very High Very High
monoamine 10 97.00 Very High Very High Very High
amygdala 12 95.28 Very High Very High Very High
Thalamus 2 71.68 Quite High
depression 22 57.16 Quite High
long-term potentiation 22 55.92 Quite High
Endocannabinoid 2 24.48 Low Low
nMDA receptor 20 5.00 Very Low Very Low Very Low
Calcium channel 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 10 85.12 High High
Stress 88 65.28 Quite High
Anxiety Disorder 14 61.36 Quite High
Depression 22 57.16 Quite High
Aggression 2 46.16 Quite Low
Cognitive Disorder 20 44.96 Quite Low
Repression 2 37.68 Quite Low
Dementia 2 18.80 Low Low
Neurodegenerative Disease 6 15.04 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, although the hippocampus plays an important role in the regulation of the HPA axis, it should be noted that other brain areas such as the prefrontal cortex [39], amygdala and bed nucleus of the stria terminalis, under the modulatory influence of monoamines from the hindbrain [40], contribute to the control of corticosteroid secretion; all these areas have reciprocal connections with the hippocampus and express nGR.
Gene_expression (express) of nGR in cortex associated with corticosteroid, hippocampus, amygdala and monoamine
1) Confidence 0.75 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.18 Pain Relevance 0.60
Whereas the unliganded nMR is primarily localized in the nucleus, the unoccupied nGR resides in the cytoplasm and only translocates to the nucleus upon ligand activation.
Gene_expression (resides) of nGR in nucleus
2) Confidence 0.65 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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