INT302427

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Rtn4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 20 98.02 Very High Very High Very High
long-term potentiation 22 82.00 Quite High
depression 22 81.36 Quite High
Calcium channel 16 77.60 Quite High
Neurotransmitter 8 64.48 Quite High
corticosteroid 196 50.00 Quite Low
Hippocampus 36 41.60 Quite Low
antagonist 16 5.00 Very Low Very Low Very Low
amygdala 12 5.00 Very Low Very Low Very Low
monoamine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 22 81.36 Quite High
Sprains And Strains 4 71.60 Quite High
Stress 88 5.00 Very Low Very Low Very Low
Cognitive Disorder 20 5.00 Very Low Very Low Very Low
Anxiety Disorder 14 5.00 Very Low Very Low Very Low
Shock 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Bordatella Infection 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their investigations revealed that synaptic transmission was potentiated when VDCCs were activated, and impaired only when NMDA receptors were activated; moreover, they found that these effects were RU 38486-sensitive, indicating their mediation by nGR.
nGR Binding (mediation) of associated with nmda receptor
1) Confidence 0.36 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.15 Pain Relevance 0.20
This effect faded upon wash-out of the hormone and was not reversible with RU 38486; assuming that RU 38486 binds specifically to nGR, the latter finding precludes mediation through nGR.
nGR Binding (binds) of
2) Confidence 0.36 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0 Pain Relevance 0.10

General Comments

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