INT302428

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.41
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Anatomy Link Frequency
spike 2
neurons 1
hippocampus 1
Rtn4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 32 98.12 Very High Very High Very High
Hippocampus 72 97.36 Very High Very High Very High
Calcium channel 32 92.12 High High
depression 44 87.40 High High
long-term potentiation 44 86.16 High High
Neuronal excitability 16 81.28 Quite High
corticosteroid 392 81.24 Quite High
nMDA receptor 40 80.68 Quite High
amygdala 24 60.96 Quite High
monoamine 20 54.24 Quite High
Disease Link Frequency Relevance Heat
Stress 176 91.12 High High
Depression 44 87.40 High High
Cognitive Disorder 40 68.00 Quite High
Anxiety Disorder 28 5.00 Very Low Very Low Very Low
Shock 20 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Bordatella Infection 8 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, 30 nM of corticosterone, which activates nGR (as well as nMR), decreased spike numbers and increased AHP amplitude, leading the authors to conclude that the bifurcating actions of low and high doses of corticosterone reflect the activation of nMR and nGR, respectively [96].
Positive_regulation (activation) of nGR in spike
1) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.09 Pain Relevance 0.23
Importantly, 30 nM of corticosterone, which activates nGR (as well as nMR), decreased spike numbers and increased AHP amplitude, leading the authors to conclude that the bifurcating actions of low and high doses of corticosterone reflect the activation of nMR and nGR, respectively [96].
Positive_regulation (activates) of nGR in spike
2) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.25
The hippocampus also serves as an important homeostatic regulator of the HPA axis upon which it exerts a strong negative drive [36,37] through the mediation of nMR and nGR [38].
Positive_regulation (mediation) of nGR in hippocampus associated with hippocampus
3) Confidence 0.49 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.24 Pain Relevance 0.55
Results from Takahashi et al. also dismissed a mediatory role for nGR or nMR in the mediation of corticosterone effects; however, they reported that the steroid prolongs the elevation of NMDAR-mediated Ca2+ influx in dissociated hippocampal neurons independently of VDCC and mobilization of intracellular Ca2+ stores [111].
Positive_regulation (role) of nGR in neurons associated with calcium channel
4) Confidence 0.49 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0 Pain Relevance 0.18

General Comments

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