INT302434

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.11 Pain Relevance 1.22

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) transmembrane transport (Prf1)

Anatomy Link Frequency pore 2 Prf1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 92 100.00 Lasting pain 23 100.00 nMDA receptor 10 77.24 long-term potentiation 11 70.32 Calcium channel 8 61.68 corticosteroid 98 53.12 dexamethasone 3 43.24 Pain threshold 9 36.76 agonist 3 15.56 Opioid 6 14.00

Disease Link Frequency Relevance Heat Pain 120 100.00 Sprains And Strains 2 73.84 Nociception 7 32.56 Stress 45 5.00 Depression 16 5.00 Cognitive Disorder 10 5.00 Shock 7 5.00 Anxiety Disorder 7 5.00 Low Back Pain 5 5.00 Neurodegenerative Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Analyses investigating the moderating effect of chronic pain complaints on the effect of the BDNF Met allele, revealed a significant interaction between pain status and the BDNF Met allele in the model of the P1- component of Fz (B?

Spec (investigating) Regulation (effect) of Transcription (model) of P1 associated with pain and lasting pain

1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.03 Pain Relevance 1.03

On the other hand, Chameau et al. [105] found by quantitative PCR that corticosterone did not change the mRNA expression of the pore-forming Cav1 subunit of the L-type Ca2+ channel, and ruled out transcriptional mechanisms in the effects they observed.

Neg (not) Regulation (change) of Transcription (expression) of pore-forming Cav1 subunit in pore

2) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.19

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