INT302435

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.23
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1)
plasma membrane (Prf1) transmembrane transport (Prf1)
Anatomy Link Frequency
pore 1
NK cells 1
Prf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 92 99.22 Very High Very High Very High
Lasting pain 23 97.28 Very High Very High Very High
chemokine 3 87.40 High High
cytokine 24 86.08 High High
Inflammation 9 85.68 High High
nMDA receptor 10 76.60 Quite High
long-term potentiation 11 69.68 Quite High
Calcium channel 8 61.68 Quite High
corticosteroid 98 52.48 Quite High
dexamethasone 3 42.60 Quite Low
Disease Link Frequency Relevance Heat
Pain 120 99.22 Very High Very High Very High
INFLAMMATION 12 85.68 High High
Adhesions 2 78.84 Quite High
Sprains And Strains 2 73.84 Quite High
Diabetes Mellitus 2 71.00 Quite High
Obesity 22 47.60 Quite Low
Uremia 1 39.04 Quite Low
Frailty 1 38.32 Quite Low
Nociception 7 32.56 Quite Low
Apoptosis 9 18.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analyses investigating the moderating effect of chronic pain complaints on the effect of the BDNF Met allele, revealed a significant interaction between pain status and the BDNF Met allele in the model of the P1- component of Fz (B?
Transcription (model) of P1 associated with pain and lasting pain
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.92 Pain Relevance 0.92
On the other hand, Chameau et al. [105] found by quantitative PCR that corticosterone did not change the mRNA expression of the pore-forming Cav1 subunit of the L-type Ca2+ channel, and ruled out transcriptional mechanisms in the effects they observed.
Transcription (expression) of pore-forming Cav1 subunit in pore
2) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.19
Moreover, leptin increases IL-2 and perforin gene expression at the transcription levels in NK cells.
Transcription (transcription) of perforin gene in NK cells
3) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.24 Pain Relevance 0.15

General Comments

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