INT302444

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.08
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
endothelial cell 6
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 6 83.20 Quite High
Inflammation 5 44.96 Quite Low
imagery 18 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thymoma 2 99.08 Very High Very High Very High
Cancer 345 97.48 Very High Very High Very High
Wound Healing 22 95.04 Very High Very High Very High
Apoptosis 29 77.36 Quite High
Stomach Cancer 3 76.76 Quite High
Prostate Cancer 3 75.68 Quite High
Metastasis 186 72.48 Quite High
Injury 50 66.16 Quite High
Targeted Disruption 9 53.04 Quite High
INFLAMMATION 5 44.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
Negative_regulation (blocking) of VEGF Binding (binding) of in endothelial cell
1) Confidence 0.57 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.13 Pain Relevance 0.04
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
Negative_regulation (blocking) of VEGF Binding (binding) of in endothelial cell
2) Confidence 0.42 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.23 Pain Relevance 0.04
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
Negative_regulation (blocking) of VEGF Binding (binding) of in endothelial cell
3) Confidence 0.41 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.14 Pain Relevance 0.04
COX: cyclooxygenase; CYP: cytochrome P450; IOD: integrated optical density; GC-MS: gas chromatography-mass spectrometry; LOX: lipoxygenase; MUFA: monounsaturated fatty acid; MVD: Micro vessel density; PUFA: polyunsaturated fatty acid; ROS: reactive oxygen species; RT-PCR: reverse transcriptase polymerase chain reaction; VEGFA: vascular endothelial growth factor A; AKT1: v-akt murine thymoma viral oncogene homolog 1.


Negative_regulation (density) of vascular endothelial growth factor Binding (cytochrome P450) of associated with thymoma
4) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.58 Pain Relevance 0

General Comments

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