INT30247

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Context Info
Confidence 0.44
First Reported 1983
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 4.45
Pain Relevance 8.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
heart 3
macrophages 2
plasma 1
pancreatic islets 1
spike 1
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 47 100.00 Very High Very High Very High
Clonidine 37 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
nociceptor 3 100.00 Very High Very High Very High
Pain 1 100.00 Very High Very High Very High
Analgesic 3 99.98 Very High Very High Very High
Kappa opioid receptor 8 99.80 Very High Very High Very High
beta blocker 1 99.44 Very High Very High Very High
Kinase C 9 99.02 Very High Very High Very High
Central nervous system 2 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Left Ventricular Dysfunction 1 99.32 Very High Very High Very High
Cv General 3 Under Development 5 98.64 Very High Very High Very High
Stress 1 98.28 Very High Very High Very High
Myocardial Infarction 3 97.92 Very High Very High Very High
Death 5 97.60 Very High Very High Very High
Nervous System Injury 1 97.38 Very High Very High Very High
Coronary Artery Disease 3 97.16 Very High Very High Very High
Hyperalgesia 9 91.32 High High
Emergencies 3 90.96 High High
Neuropathic Pain 7 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beta adrenoceptor antagonists are effective in the symptomatic management of angina pectoris.
Regulation (effective) of Beta adrenoceptor associated with angina and antagonist
1) Confidence 0.44 Published 1985 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 2860771 Disease Relevance 0.17 Pain Relevance 0.29
The present work was undertaken to study the effects of alpha(2)-adrenoceptor antagonist 2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydro-2-propyl-pyrrolo[3,2,1-hi]-indole hydrochloride (SL 84.0418) on the neocortical spike-and-wave spindling episodes (S and W) in the cortical electroencephalogram (ECoG) of DBA/2J mice.
Regulation (effects) of adrenoceptor in spike associated with antagonist
2) Confidence 0.36 Published 2003 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12551737 Disease Relevance 0 Pain Relevance 0.09
Atenolol, by contrast, had the predicted effects of a beta adrenoceptor antagonist on heart rate during exercise and the Valsalva maneuver.
Regulation (effects) of adrenoceptor in heart associated with antagonist
3) Confidence 0.35 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677387 Disease Relevance 0.55 Pain Relevance 0.37
The data suggest that changes in alpha 2 adrenoceptor population parameters may be a general characteristics of antidepressant treatment, but not necessarily followed by changes in clonidine effects.
Regulation (changes) of adrenoceptor associated with antidepressant and clonidine
4) Confidence 0.32 Published 1985 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 3008133 Disease Relevance 0.17 Pain Relevance 0.52
Nerve injury enhanced the analgesic efficacy of the alpha(2) adrenoceptor agonist dexmedetomidine, and paradoxically also induced an analgesic response to alpha(2) adrenoceptor antagonists.
Regulation (response) of adrenoceptor in Nerve associated with nervous system injury, antagonist, analgesic and agonist
5) Confidence 0.19 Published 2000 Journal Pain Section Abstract Doc Link 10781908 Disease Relevance 1.22 Pain Relevance 1.44
Cardiopulmonary effects of clonidine, diazepam and the peripheral alpha 2 adrenoceptor agonist ST-91 in conscious sheep.
Regulation (effects) of adrenoceptor associated with agonist and clonidine
6) Confidence 0.16 Published 1997 Journal J. Vet. Pharmacol. Ther. Section Title Doc Link 9430771 Disease Relevance 0.09 Pain Relevance 0.37
Effects of alpha-adrenoceptor agonists and antagonists on insulin secretion, calcium uptake, and rubidium efflux in mouse pancreatic islets.
Regulation (Effects) of adrenoceptor in pancreatic islets associated with antagonist and agonist
7) Confidence 0.09 Published 1983 Journal Acta Physiol. Scand. Section Title Doc Link 6137936 Disease Relevance 0.09 Pain Relevance 0.51
Inhibitors of p38 MAPK prevented the stimulatory effects of alpha(2)-adrenoceptor agonists on IL-12 production.
Regulation (effects) of adrenoceptor associated with agonist
8) Confidence 0.05 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.53
This study was designed to determine if alpha(2)-adrenoceptor agonists are involved in the induction of interleukin-12 production by macrophages. alpha(2)-adrenoceptor agonists such as clonidine, guanfacine, and oxymetazoline significantly induced interleukin-12 secretion and interleukin-12 mRNA expression by macrophages in a concentration-dependent manner.
Regulation (involved) of adrenoceptor in macrophages associated with agonist and clonidine
9) Confidence 0.05 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.34
These findings show that alpha(2)-adrenoceptor agonists induce interleukin-12 production in mouse macrophages via a PKC/p38 MAPK signaling pathway and suggest that the effect of alpha(2)-adrenoceptor agonists on interleukin-12 secretion may be a new and novel means of augmenting cell-mediated immune responses.
Regulation (effect) of adrenoceptor in macrophages associated with kinase c and agonist
10) Confidence 0.05 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12706479 Disease Relevance 0 Pain Relevance 0.53
In elective surgical patients, there was no effect of beta-adrenoceptor or calcium entry channel blockade, diuretics or digoxin on cardiac death after adjusting for confounding variables.
Neg (no) Regulation (effect) of beta-adrenoceptor associated with death
11) Confidence 0.05 Published 2001 Journal Br J Anaesth Section Abstract Doc Link 11573623 Disease Relevance 0.65 Pain Relevance 0.08
Effect of alpha-adrenoceptor agonists and antagonists on imipramine-induced antinociception in the rat formalin test.
Regulation (Effect) of adrenoceptor associated with antinociception, nociceptor, antagonist and agonist
12) Confidence 0.04 Published 2002 Journal Pharmacology Section Title Doc Link 11893901 Disease Relevance 0 Pain Relevance 1.30
Differential hemodynamic effects of beta-adrenoceptor blockers, Ca antagonists and combined alpha-beta-receptor blockade in ischemic heart disease.
Regulation (effects) of beta-adrenoceptor in heart associated with coronary artery disease and antagonist
13) Confidence 0.03 Published 1986 Journal Acta Med Scand Section Title Doc Link 2869648 Disease Relevance 0.41 Pain Relevance 0.18
The role of serotonin (5-HT) in generating the spontaneous preovulatory surge of luteinizing hormone (LH) has been investigated by studying the effect of ketanserin (a mixed 5-HT2/alpha 1 adrenoreceptor antagonist); the selective 5-HT2 receptor antagonist, ritanserin; and the selective alpha 1 adrenoreceptor antagonist, prazosin, on the plasma concentrations of LH during the afternoon of proestrus in conscious Wistar rats.
Regulation (effect) of adrenoreceptor in plasma associated with antagonist and serotonin
14) Confidence 0.03 Published 1994 Journal Psychoneuroendocrinology Section Abstract Doc Link 8047643 Disease Relevance 0 Pain Relevance 0.32
The beneficial effects of beta-adrenoceptor antagonists (beta-blockers) on cardiac function in heart failure due to anthracyclines seem comparable with those observed in other forms of heart failure with systolic dysfunction.
Regulation (effects) of beta-adrenoceptor in heart associated with beta blocker, antagonist and myocardial infarction
15) Confidence 0.03 Published 2005 Journal Paediatr Drugs Section Abstract Doc Link 15871628 Disease Relevance 1.10 Pain Relevance 0.18
In this region, subsensitivity to the inhibitory effect of both UK14,304 and U69,593, respectively alpha(2A)-adrenoceptor and kappa-opioid receptor agonist, on the peristaltic reflex developed after chronic desipramine treatment.
Regulation (effect) of adrenoceptor associated with desipramine, agonist and kappa opioid receptor
16) Confidence 0.02 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17055479 Disease Relevance 0 Pain Relevance 0.73
In this study, the ability of the nonselective adenosine receptor antagonist caffeine to influence the concentration of noradrenaline in the central nervous system was investigated, and its effects compared with those of alpha-2 adrenoceptor modulation.
Regulation (modulation) of adrenoceptor in central nervous system associated with adenocard, antagonist, noradrenaline and central nervous system
17) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152369 Disease Relevance 0 Pain Relevance 0.57
The effects of the alpha-2 adrenoceptor agonist clonidine (CLO) on the growth hormone (GH) regulatory neuronal systems, growth hormone-releasing hormone (GHRH) and somatostatin (SS), were studied in adult male rats given a single or a short-term administration (1, 3 and 6 days) of the drug.
Regulation (effects) of adrenoceptor in neuronal associated with somatostatin, agonist and clonidine
18) Confidence 0.00 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 0.59

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