INT302483

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.96
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (MAGT1) endoplasmic reticulum (MAGT1) plasma membrane (MAGT1)
Anatomy Link Frequency
myometrium 1
MAGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 8 90.48 High High
cva 28 43.12 Quite Low
Inflammation 40 5.00 Very Low Very Low Very Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
Dismenorea 8 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 100 98.80 Very High Very High Very High
Premature Birth 282 93.00 High High
Pre-eclampsia 10 85.24 High High
Pre-term Labor 40 85.20 High High
Reprotox - General 3 36 84.32 Quite High
Habitual Abortion 4 83.80 Quite High
Birth Weight 10 75.84 Quite High
Malaria 18 73.24 Quite High
Stress 42 49.12 Quite Low
Hemorrhage 28 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a critical need for a better understanding of the immunologic regulation of trophoblast invasion, and how environmental factors including chronic intrauterine infection, or exposure to environmental toxicants (e.g., cigarette smoke and insecticides) or other xenobiotic agents that may influence implantation.


Spec (may) Regulation (influence) of implantation associated with infection
1) Confidence 0.01 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.56 Pain Relevance 0.05
The following list includes critical gaps and needs in improving our understanding of these processes that are so important to survival:

• Factors regulating implantation, and the potential impact of infection or xenobiotics in normal and abnormal placentation • Factors regulating uterine quiescence, and the role of progesterone in preventing preterm birth • Mechanisms responsible for activation of the myometrium from a state of quiescence to a state of contractility • Appropriate animal models to replicate pathway-specific etiologies of preterm birth or stillbirth that will contribute to rational and efficacious interventions • The role of environmental exposure and xenobiotics in activation and stimulation of contractions • The contributions of both the fetal and the maternal genotype in determining the clinical outcome (i.e., the phenotype) of preterm labor and stillbirth • The role of gene:environment interactions in preterm birth and stillbirth • The pathophysiology of common systemic infections like malaria in preterm birth and stillbirth • The application of systems biology to better understand the complexity of parturition

Regulation (regulating) of implantation in myometrium associated with malaria, premature birth, pre-term labor and infection
2) Confidence 0.01 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 1.40 Pain Relevance 0

General Comments

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