INT302544

Context Info Confidence 0.34 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 1.89 Pain Relevance 0.62

plasma membrane (Cd86)

Anatomy Link Frequency CD86 5 macrophage 2 B cells 2 alveolar macrophages 1 Cd86 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 47 90.12 cytokine 88 86.24 Adalimumab 8 83.28 Deep tissue 2 80.12 rheumatoid arthritis 51 79.96 Arthritis 8 14.80 Inflammation 22 5.00 Pain 8 5.00 chemokine 6 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Infection 7 99.42 Cancer 191 98.96 Targeted Disruption 10 85.92 Hypersensitivity 1 81.76 Salivary Gland Disease 18 81.36 Rheumatoid Arthritis 51 79.96 Malignant Neoplastic Disease 3 79.84 Sprains And Strains 13 79.20 Necrosis 14 70.80 Fever 10 60.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As B cells are being activated, they up-regulate surface expression of co-stimulatory molecules such as CD80 and CD86.

Regulation (regulate) of CD86 in B cells

1) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0

Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.

Regulation (evaluated) of CD86 in B cells

2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13

Changes in CD86 and TNF?

Regulation (Changes) of CD86 in CD86

3) Confidence 0.28 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.03

Inhibition of MEK prevents up-regulation of CD86

Regulation (regulation) of CD86 in CD86

4) Confidence 0.28 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.04

IL-4 can also act on APCs to polarize them during an active infection and it has been shown to up-regulate CD86 on human alveolar macrophages via ERK1/2 and JAK/STAT6 pathways [41].

Regulation (regulate) of CD86 in alveolar macrophages associated with infection

5) Confidence 0.28 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0.10 Pain Relevance 0.06

g/mL of SGE indicate that regulation of CD86 is concentration dependent. 10 ?

Regulation (regulation) of CD86 in CD86

6) Confidence 0.28 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.07

Furthermore, up-regulated levels of the maturation markers CD80 and CD86 were found in CD11c+ subpopulation recovered from HIFU-treated tumors (Figure 6B, D, and 6E), indicating HIFU-treatment induced infiltrated DCs towards a mature phenotype.

Regulation (regulated) of CD86 in CD86 associated with cancer

7) Confidence 0.22 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.99 Pain Relevance 0

Notably, the change affecting CD86 paralleled a reduction in the intensity of Fc?

Regulation (affecting) of CD86 in CD86

8) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.42 Pain Relevance 0.26

Molecules in SGE of R. microplus have a concentration-dependent effect on differential up-regulation of CD86 in a macrophage cell line activated by the TLR4 ligand, LPS.

Regulation (regulation) of CD86 in macrophage

9) Confidence 0.17 Published 2010 Journal Parasit Vectors Section Abstract Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.03

Molecules in SGE of R. microplus have a concentration-dependent effect on differential up-regulation of CD86 in a macrophage cell line activated by the TLR4-ligand, LPS.

Regulation (regulation) of CD86 in macrophage

10) Confidence 0.17 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0.29 Pain Relevance 0

General Comments

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