INT302613

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 3.70
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
capillary 2
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 13 79.60 Quite High
ischemia 26 38.92 Quite Low
antagonist 13 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 78 98.72 Very High Very High Very High
Cancer 1105 98.44 Very High Very High Very High
Mevalonate Kinase Deficiency 174 95.28 Very High Very High Very High
INFLAMMATION 25 78.16 Quite High
Injury 26 62.84 Quite High
Wound Healing 13 46.36 Quite Low
Cv Unclassified Under Development 52 38.92 Quite Low
Increased Venous Pressure Under Development 26 37.64 Quite Low
Pathologic Neovascularization 39 32.56 Quite Low
Stress 26 29.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we report that active levels of Rac1 are increased in ?
Positive_regulation (increased) of Gene_expression (levels) of Rac1
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.77 Pain Relevance 0
However, we report that active levels of Rac1 are increased in ?
Positive_regulation (active) of Gene_expression (levels) of Rac1
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.77 Pain Relevance 0
Vania Braga, Imperial College, London, UK), was used to pull down active Rac1 and Cdc42 from MLEC cell lysates transfected with scrambled or Rac1 siRNA.
Positive_regulation (active) of Gene_expression (transfected) of Rac1
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Vania Braga, Imperial College, London, UK), was used to pull down active Rac1 and Cdc42 from MLEC cell lysates transfected with scrambled or Rac1 siRNA.
Positive_regulation (active) of Gene_expression (transfected) of Rac1 siRNA
4) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Vania Braga, Imperial College, London, UK), was used to pull down active Rac1 and Cdc42 from MLEC cell lysates transfected with scrambled or Rac1 siRNA.
Positive_regulation (transfected) of Gene_expression (transfected) of Rac1 siRNA
5) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
3-null mice were transfected with either a scrambled control (Con) or Rac1-specific siRNA.
Positive_regulation (transfected) of Gene_expression (transfected) of Rac1
6) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
This suggested that the elevated Rac1 activity that occurs in ?
Positive_regulation (elevated) of Gene_expression (activity) of Rac1
7) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
We provide evidence that Rac1 activity (Rac1-GTP) is elevated in ?
Positive_regulation (elevated) of Gene_expression (activity) of Rac1
8) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.77 Pain Relevance 0
Our observations also support the notion that, in 3D environments, Rac1 is dispensable for VEGF-mediated capillary-formation in wild-type but not ?
Positive_regulation (environments) of Gene_expression (dispensable) of Rac1 in capillary
9) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.15 Pain Relevance 0.08
One day before setting up the 3D migration assays, Con- and Rac1- siRNA transfected ?
Positive_regulation (transfected) of Gene_expression (transfected) of Rac1
10) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.12 Pain Relevance 0
We provide evidence that Rac1 activity (Rac1-GTP) is elevated in ?
Positive_regulation (elevated) of Gene_expression (activity) of Rac1
11) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.77 Pain Relevance 0
Vania Braga, Imperial College, London, UK), was used to pull down active Rac1 and Cdc42 from MLEC cell lysates transfected with scrambled or Rac1 siRNA.
Positive_regulation (transfected) of Gene_expression (transfected) of Rac1
12) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
This suggested that the elevated Rac1 activity that occurs in ?
Positive_regulation (occurs) of Gene_expression (activity) of Rac1
13) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Combination of membrane and soluble fraction separation and activated RhoA and Rac1 assessment assays
Positive_regulation (activated) of Gene_expression (assays) of Rac1
14) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0 Pain Relevance 0
Levels of membrane-bound Rac1 also decreased upon incubation with increasing simvastatin concentrations, paralleled with increasing levels of soluble Rac1 (Fig. 1g, h).
Positive_regulation (increasing) of Gene_expression (levels) of Rac1
15) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.34 Pain Relevance 0
Activated RhoA and Rac1 assessment assays
Positive_regulation (Activated) of Gene_expression (assays) of Rac1
16) Confidence 0.33 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0 Pain Relevance 0

General Comments

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