INT302615

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 4 27.12 Quite Low
ischemia 8 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Inward rectifier potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 378 93.52 High High
Skin Cancer 8 83.20 Quite High
Glioma 33 73.64 Quite High
Adhesions 36 57.28 Quite High
Targeted Disruption 24 31.00 Quite Low
INFLAMMATION 4 26.88 Quite Low
Apoptosis 2 26.80 Quite Low
Metastasis 15 8.32 Low Low
Colorectal Cancer 16 5.00 Very Low Very Low Very Low
Injury 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that the enhanced Rac1 activity in ?
Transcription (activity) of Rac1
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.27 Pain Relevance 0
3-null mice reduced significantly Rac1 mRNA levels (Figure 7A), total protein levels (Figure 7B), and active Rac1 levels (Figure 1A).
Transcription (levels) of Rac1
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
In addition, Trypan blue exclusion showed that the percentage of cells that were viable did not change after Rac1-depletion between 1-3 days after seeding in either genotype (Figure 8B).
Neg (not) Transcription (change) of Rac1-depletion
3) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
As expected, no significant changes in either mRNA or protein levels of Rac1 or Flk-1 were observed in pSico-Con infected cells (Figure 2B).
Transcription (levels) of Rac1
4) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0
Rac1 mRNA levels reduced only in MC-sh treated 5310 cells.
Transcription (levels) of Rac1
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.36 Pain Relevance 0

General Comments

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