INT302615

Context Info Confidence 0.66 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.10 Pain Relevance 0

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1) cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)

Rac1 (Mus musculus)

Pain Link Frequency Relevance Heat cINOD 4 27.12 ischemia 8 5.00 metalloproteinase 4 5.00 antagonist 4 5.00 Central nervous system 1 5.00 anesthesia 1 5.00 potassium channel 1 5.00 Inward rectifier potassium channel 1 5.00

Disease Link Frequency Relevance Heat Cancer 378 93.52 Skin Cancer 8 83.20 Glioma 33 73.64 Adhesions 36 57.28 Targeted Disruption 24 31.00 INFLAMMATION 4 26.88 Apoptosis 2 26.80 Metastasis 15 8.32 Colorectal Cancer 16 5.00 Injury 16 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We show that the enhanced Rac1 activity in ?

Transcription (activity) of Rac1

1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.27 Pain Relevance 0

3-null mice reduced significantly Rac1 mRNA levels (Figure 7A), total protein levels (Figure 7B), and active Rac1 levels (Figure 1A).

Transcription (levels) of Rac1

2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0

In addition, Trypan blue exclusion showed that the percentage of cells that were viable did not change after Rac1-depletion between 1-3 days after seeding in either genotype (Figure 8B).

Neg (not) Transcription (change) of Rac1-depletion

3) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0

As expected, no significant changes in either mRNA or protein levels of Rac1 or Flk-1 were observed in pSico-Con infected cells (Figure 2B).

Transcription (levels) of Rac1

4) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0

Rac1 mRNA levels reduced only in MC-sh treated 5310 cells.

Transcription (levels) of Rac1

5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.36 Pain Relevance 0

General Comments

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