INT302621

Context Info Confidence 0.43 First Reported 2010 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1) cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)

Anatomy Link Frequency endothelial cells 2 Rac1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 4 5.00 cINOD 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Cancer 170 50.00 Targeted Disruption 12 5.00 Colorectal Cancer 8 5.00 Cv Unclassified Under Development 8 5.00 Metastasis 6 5.00 Pathologic Neovascularization 6 5.00 Adhesions 4 5.00 Injury 4 5.00 Hemangiosarcoma 4 5.00 Skin Cancer 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Importantly, knockdown of Rac1 had no effect on VEGF-induced 3D chemotactic migration of wild-type endothelial cells, but did inhibit this mode of migration in ?

Neg (no) Regulation (effect) of Negative_regulation (knockdown) of Rac1 in endothelial cells

1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0

Rac1 depletion does not affect VEGF-receptor2 expression

Neg (not) Regulation (affect) of Negative_regulation (depletion) of Rac1

2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0

General Comments

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