INT302624
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Taken together, these data indicate that, while no biological effect of Rac-1 knockdown was observed in wild-type/Tie1-Cre+, the lentivirus treatment efficiently reduced expression of Rac1 in tumor blood vessels from these animals. | |||||||||||||||
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3-null endothelial cells, since we have shown, that by inhibiting Rac1 expression alone, we can reduce the enhanced angiogenic responses of ? | |||||||||||||||
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Here we show that depletion of endothelial Rac1 expression in adult mice, unexpectedly, has no effect on tumor growth or tumor angiogenesis. | |||||||||||||||
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3-null mice were all dependent on endothelial Rac1 expression since Rac1-depletion in ? | |||||||||||||||
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However, pSico-Rac1 treatment had no effect in wild-type/Tie1-Cre+ mice, but did inhibit neovascularization in ? | |||||||||||||||
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3-null mice were all dependent on endothelial Rac1 expression since Rac1-depletion in ? | |||||||||||||||
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3-null mice reduced significantly Rac1 mRNA levels (Figure 7A), total protein levels (Figure 7B), and active Rac1 levels (Figure 1A). | |||||||||||||||
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Taken together these data suggest that Rac1 expression in endothelial cells is not essential for VEGF-mediated angiogenesis in wild-type mice but is involved in such responses in ? | |||||||||||||||
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General Comments
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