INT302624

Context Info Confidence 0.56 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 8 Disease Relevance 3.67 Pain Relevance 0.06

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1) cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)

Anatomy Link Frequency endothelial cells 4 blood vessels 2 Rac1 (Mus musculus)

Pain Link Frequency Relevance Heat cINOD 8 59.64 ischemia 16 16.24 antagonist 8 5.00

Disease Link Frequency Relevance Heat Cancer 680 99.84 Repression 8 92.32 Infection 16 84.24 Pathologic Neovascularization 24 69.48 INFLAMMATION 8 59.40 Skin Cancer 16 54.52 Cv Unclassified Under Development 32 16.24 Targeted Disruption 48 5.00 Colorectal Cancer 32 5.00 Metastasis 24 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Taken together, these data indicate that, while no biological effect of Rac-1 knockdown was observed in wild-type/Tie1-Cre+, the lentivirus treatment efficiently reduced expression of Rac1 in tumor blood vessels from these animals.

Negative_regulation (reduced) of Gene_expression (expression) of Rac1 in blood vessels associated with cancer

1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.93 Pain Relevance 0

3-null endothelial cells, since we have shown, that by inhibiting Rac1 expression alone, we can reduce the enhanced angiogenic responses of ?

Negative_regulation (inhibiting) of Gene_expression (expression) of Rac1 in endothelial cells

2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.18 Pain Relevance 0.06

Here we show that depletion of endothelial Rac1 expression in adult mice, unexpectedly, has no effect on tumor growth or tumor angiogenesis.

Negative_regulation (depletion) of Gene_expression (expression) of Rac1 associated with cancer

3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2842301 Disease Relevance 0.76 Pain Relevance 0

3-null mice were all dependent on endothelial Rac1 expression since Rac1-depletion in ?

Negative_regulation (endothelial) of Gene_expression (expression) of Rac1

4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.81 Pain Relevance 0

However, pSico-Rac1 treatment had no effect in wild-type/Tie1-Cre+ mice, but did inhibit neovascularization in ?

Negative_regulation (inhibit) of Gene_expression (treatment) of pSico-Rac1

5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.19 Pain Relevance 0

3-null mice were all dependent on endothelial Rac1 expression since Rac1-depletion in ?

Negative_regulation (endothelial) of Gene_expression (expression) of Rac1-depletion

6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.81 Pain Relevance 0

3-null mice reduced significantly Rac1 mRNA levels (Figure 7A), total protein levels (Figure 7B), and active Rac1 levels (Figure 1A).

Negative_regulation (reduced) of Gene_expression (levels) of Rac1

7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0

Taken together these data suggest that Rac1 expression in endothelial cells is not essential for VEGF-mediated angiogenesis in wild-type mice but is involved in such responses in ?

Neg (not) Negative_regulation (involved) of Gene_expression (expression) of Rac1 in endothelial cells

8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0

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