INT302664

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2)
intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)
SMAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 100 96.32 Very High Very High Very High
fibrosis 55 86.88 High High
addiction 1 36.08 Quite Low
Inflammation 36 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 50 86.88 High High
Nephrotoxicity 3 81.40 Quite High
Apoptosis 15 79.36 Quite High
Renal Failure 1 76.36 Quite High
Diabetes Mellitus 3 72.64 Quite High
Internal Fibrosis 16 71.24 Quite High
Ureteral Obstruction 4 58.76 Quite High
Chronic Renal Failure 1 54.16 Quite High
Renal Disease 6 32.68 Quite Low
Disease Progression 1 30.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced Smad2-phosphorylation, 3TP-lux promoter activity and generation of ROS.
Positive_regulation (induced) of Smad2
1) Confidence 0.49 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.70 Pain Relevance 0.18
In order to rule out Smad2 activation, PSmad2 expression was assessed by Western blot.
Positive_regulation (activation) of Smad2
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.15 Pain Relevance 0.46

General Comments

This test has worked.

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