INT302676

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.12
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1, MFN2) GTPase activity (OPA1, MFN2) cytosol (MFN2)
mitochondrion organization (OPA1)
Anatomy Link Frequency
respiratory 1
OPA1 (Homo sapiens)
MFN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
peripheral neuropathy 8 86.44 High High
Multiple sclerosis 10 69.00 Quite High
Migraine 4 26.32 Quite Low
headache 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Electroencephalography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Optic Atrophy 15 89.52 High High
Peripheral Neuropathy 8 86.44 High High
Neuropathic Pain 8 80.28 Quite High
Disease 20 78.52 Quite High
Charcot Marie Tooth Disease 2 77.72 Quite High
Demyelinating Disease 12 69.00 Quite High
Parkinson's Disease 3 64.24 Quite High
Leber Hereditary Optic Atrophy 3 55.48 Quite High
Diabetes Mellitus 2 51.92 Quite High
Neurological Disease 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitofusin-2 interacts closely with Opa1 to promote fusion of the mitochondrial network, and it could also play a distinct role in mitochondrial oxidative output by regulating the expression of nuclear-encoded respiratory chain subunits (Pich et al., 2005).
Opa1 Binding (interacts) of Mitofusin-2 in respiratory
1) Confidence 0.46 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 1.12 Pain Relevance 0.14

General Comments

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