INT302693

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.00
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (C10orf2) cell death (C10orf2)
C10orf2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 2 75.00 Quite High
peripheral neuropathy 16 69.60 Quite High
Inflammation 4 65.96 Quite High
Electroencephalography 2 28.64 Quite Low
Multiple sclerosis 20 5.00 Very Low Very Low Very Low
Migraine 8 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 40 90.44 High High
Eye Disease 2 86.08 High High
Syndrome 12 78.48 Quite High
Liver Failure 2 73.76 Quite High
Epilepsy 2 72.16 Quite High
Ataxia 22 70.24 Quite High
Peripheral Neuropathy 16 69.60 Quite High
Optic Atrophy 30 68.28 Quite High
Muscle Disease 18 67.52 Quite High
INFLAMMATION 4 65.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Visual failure was a prominent feature of their phenotypes and when initial screens for POLG1, POLG2, PEO1 and SLC25A4 were found to be negative, OPA1 sequencing was performed.
Localization (screens) of PEO1
1) Confidence 0.59 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.37 Pain Relevance 0.03
Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).
Localization (accumulation) of PEO1
2) Confidence 0.59 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.63 Pain Relevance 0.07

General Comments

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