INT302700

Context Info Confidence 0.65 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.65 Pain Relevance 0.07

mitochondrion (TK2) small molecule metabolic process (TK2) kinase activity (TK2)

TK2 (Homo sapiens)

Pain Link Frequency Relevance Heat adenocard 1 75.00 peripheral neuropathy 8 71.76 Multiple sclerosis 10 5.00 Migraine 4 5.00 headache 3 5.00 Inflammation 2 5.00 Spinal cord 1 5.00 Electroencephalography 1 5.00

Disease Link Frequency Relevance Heat Disease 20 84.72 Syndrome 6 80.64 Liver Failure 1 75.92 Epilepsy 1 74.32 Ataxia 11 72.40 Peripheral Neuropathy 8 71.76 Muscle Disease 9 69.68 Chronic Progressive External Ophthalmoplegia 11 67.92 Mitochondrial Disorders 4 54.64 Neurological Disease 2 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).

Localization (accumulation) of TK2

1) Confidence 0.65 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.65 Pain Relevance 0.07

General Comments

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