INT302729

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.86
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hk2) carbohydrate metabolic process (Hk2) kinase activity (Hk2)
Anatomy Link Frequency
body 3
muscle 2
skeletal muscle 1
Hk2 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 266 94.96 High High
imagery 42 5.00 Very Low Very Low Very Low
anesthesia 21 5.00 Very Low Very Low Very Low
ketamine 14 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Sciatic nerve 7 5.00 Very Low Very Low Very Low
Calcium channel 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 42 99.44 Very High Very High Very High
Body Weight 21 98.56 Very High Very High Very High
Reperfusion Injury 49 95.72 Very High Very High Very High
Cv Unclassified Under Development 259 94.96 High High
Injury 126 88.44 High High
Stress 14 70.76 Quite High
Death 98 62.24 Quite High
Apoptosis 7 52.24 Quite High
Cancer 7 49.12 Quite Low
Hyperemia 7 8.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male and female heterozygote knockout HKII (HK+/-), heterozygote overexpressed HKII (HKtg), and their wild-type (WT) C57Bl/6 littermates mice were examined.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HKII associated with targeted disruption
1) Confidence 0.68 Published 2010 Journal Pflugers Arch Section Abstract Doc Link PMC2842566 Disease Relevance 0.60 Pain Relevance 0.13
However, force producing capacity, expressed per muscle weight, is not affected by overexpressing HKII.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HKII in muscle
2) Confidence 0.68 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.34 Pain Relevance 0
Thus, overexpressing HKII unexpectedly retards growth of skeletal muscle and body weight.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HKII in body associated with body weight
3) Confidence 0.59 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.29 Pain Relevance 0
To study alterations in the level of HK, we make use of two different HKII genotypes: the C57Bl/6 mice with a partial deletion of HKII [12; HK+/-] as well as mice overexpressing HKII (HKtg) [2].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HKII
4) Confidence 0.49 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.49 Pain Relevance 0.04
To study alterations in the level of HK, we make use of two different HKII genotypes: the C57Bl/6 mice with a partial deletion of HKII [12; HK+/-] as well as mice overexpressing HKII (HKtg) [2].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HKII
5) Confidence 0.49 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.42 Pain Relevance 0.04
Overexpressing HKII resulted in a robust increase in HK activity (360% for male and 480% for female).
Positive_regulation (Overexpressing) of Gene_expression (Overexpressing) of HKII
6) Confidence 0.43 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.43 Pain Relevance 0
Thus, overexpressing HKII unexpectedly retards growth of skeletal muscle and body weight.
Positive_regulation (overexpressing) of in skeletal muscle Gene_expression (overexpressing) of HKII in body associated with body weight
7) Confidence 0.20 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2842566 Disease Relevance 0.29 Pain Relevance 0

General Comments

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