INT30276

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 39
Total Number 43
Disease Relevance 11.28
Pain Relevance 24.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 11
spinal cord 6
CPu 4
dorsal horn 4
granule cell 4
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 199 100.00 Very High Very High Very High
Opioid 59 100.00 Very High Very High Very High
agonist 23 99.98 Very High Very High Very High
dopamine receptor 12 99.96 Very High Very High Very High
mu opioid receptor 32 99.84 Very High Very High Very High
spinal dorsal horn 3 99.84 Very High Very High Very High
Dopamine 390 99.68 Very High Very High Very High
cocaine 42 99.58 Very High Very High Very High
Morphine 20 99.54 Very High Very High Very High
Arthritis 1 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Middle Cerebral Artery Infarction 8 99.98 Very High Very High Very High
Nervous System Injury 5 99.98 Very High Very High Very High
Neurodegenerative Disease 13 99.86 Very High Very High Very High
Nociception 42 99.68 Very High Very High Very High
Generalized Anxiety Disorder 11 99.48 Very High Very High Very High
Arthritis 1 99.48 Very High Very High Very High
Hyperalgesia 31 99.36 Very High Very High Very High
Spinal Cord Injury 3 99.20 Very High Very High Very High
INFLAMMATION 73 98.64 Very High Very High Very High
Neuropathic Pain 12 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third-generation lentiviral vectors were used to overexpress the prodynorphin gene, previously shown to orchestrate a dynorphinergic system acting as a major conductor of embryonic stem cell cardiogenesis.
Positive_regulation (overexpress) of Gene_expression (overexpress) of prodynorphin in embryonic stem cell
1) Confidence 0.67 Published 2007 Journal Regenerative medicine Section Body Doc Link 17465751 Disease Relevance 0 Pain Relevance 0
Treatment of MIN6 cells with KCl, forskolin, or isobutyl-methyl-xanthine strongly induced prodynorphin RNA expression, suggesting that induction may be related to secretion-coupled signaling pathways.
Positive_regulation (induced) of Gene_expression (expression) of prodynorphin
2) Confidence 0.67 Published 1998 Journal Endocrinology Section Abstract Doc Link 9751516 Disease Relevance 0.06 Pain Relevance 0.39
In addition to a transient increase in neurogenesis, MCAO caused a transient up-regulation of preprodynorphin and preproenkephalin mRNA expression in the granule cell layer.
Positive_regulation (caused) of Gene_expression (expression) of preprodynorphin in granule cell associated with middle cerebral artery infarction and neurodegenerative disease
3) Confidence 0.67 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18331339 Disease Relevance 1.25 Pain Relevance 0.50
In addition to a transient increase in neurogenesis, MCAO caused a transient up-regulation of preprodynorphin and preproenkephalin mRNA expression in the granule cell layer.
Positive_regulation (up-regulation) of Gene_expression (expression) of preprodynorphin in granule cell associated with middle cerebral artery infarction and neurodegenerative disease
4) Confidence 0.67 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18331339 Disease Relevance 1.24 Pain Relevance 0.50
CONCLUSIONS: We interpret our findings to indicate that acute nicotine enhances the synthesis and release of striatal Dyn.
Positive_regulation (enhances) of Gene_expression (synthesis) of Dyn
5) Confidence 0.61 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 18807250 Disease Relevance 0 Pain Relevance 0
The preliminary Sep-Pak chromatography method excludes alpha-neoendorphin and the dynorphins and thus provides a suitable procedure for separation of prodynorphin and proenkephalin products.
Positive_regulation (separation) of Gene_expression (products) of proenkephalin
6) Confidence 0.50 Published 1985 Journal J Pharmacol Methods Section Abstract Doc Link 3999758 Disease Relevance 0 Pain Relevance 0
Dynorphin A (DYN A) injected intrathecally in the rat produced a significant elevation of the nociceptive threshold, measured by the tail flick test.
Positive_regulation (elevation) of Gene_expression (produced) of DYN in tail associated with nociception, dynorphin and tail-flick
7) Confidence 0.48 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2861098 Disease Relevance 0.25 Pain Relevance 0.29
DRD1 and PDyn mRNA levels were significantly upregulated in KO animals as compared to controls (Fig. 5A and B).
Positive_regulation (upregulated) of Gene_expression (levels) of PDyn mRNA
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.54
However, DRD1 and PDyn mRNA levels were significantly elevated in striatonigral projecting neurons.
Positive_regulation (elevated) of Gene_expression (levels) of PDyn mRNA in neurons
9) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.30 Pain Relevance 0.50
The above results indicate that repeated morphine leads to long-lasting upregulation of the PDYN gene expression in the mouse nucleus accumbens and striatum; on the other hand, the PENK and D2 mRNA gene expressions are either inhibited or remain unchanged, significant changes being observed in the nucleus accumbens only.
Positive_regulation (upregulation) of Gene_expression (expression) of PDYN gene in nucleus accumbens associated with nucleus accumbens and morphine
10) Confidence 0.41 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.96
Prodynorphin messenger RNA expression and dynorphin A (1-17)-like immunoreactivity on the ipsilateral side of the spinal cord were markedly increased in complete Freund's adjuvant-injected mice.
Positive_regulation (increased) of Gene_expression (expression) of Prodynorphin in spinal cord
11) Confidence 0.41 Published 2010 Journal Anesthesiology Section Body Doc Link 20068450 Disease Relevance 0 Pain Relevance 0
While no changes in DA release or uptake could be detected by microdialysis, KO animals showed a significant increase in total DA tissue content in dorsal striatum, an effect accompanied by a significant increase in striatal prodynorphin and DRD1 mRNA expression levels.
Positive_regulation (increase) of Gene_expression (expression) of prodynorphin in striatum associated with dopamine
12) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.12 Pain Relevance 0.61
However, the catecholamine/Dyn ratio in the tissue extract (138 000) was much higher than that found in the cell extract (20 180), suggesting a possible selective degradation of Dyn in tissue extract as compared with cell extract or an induction of Dyn biosynthesis in cells which have been isolated from their natural microenvironment.
Positive_regulation (induction) of Gene_expression (biosynthesis) of Dyn associated with catecholamine
13) Confidence 0.38 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6203634 Disease Relevance 0 Pain Relevance 0.60
During the postnatal period, the levels of striatal DYN steadily increased in an age-dependent fashion and appeared to peak between 35 and 45 days.
Positive_regulation (increased) of Gene_expression (levels) of DYN
14) Confidence 0.34 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8868307 Disease Relevance 0 Pain Relevance 0.43
DMSO-primed GATA-4 and Nkx-2.5 gene expression was preceded by a marked increase in prodynorphin gene expression and dynorphin B synthesis and secretion.
Positive_regulation (increase) of Gene_expression (synthesis) of dynorphin B associated with dynorphin
15) Confidence 0.32 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.58
The kindling was very effective in increasing the hippocampal levels of IR-DYN, alpha-neoendorphin and Leu-enkephalin, but remained without any significant effect on the levels of IR-DYN and beta-endorphin in the majority of brain structures studied.
Positive_regulation (increasing) of Gene_expression (levels) of IR-DYN in brain structures associated with enkephalin
16) Confidence 0.31 Published 1983 Journal Regul. Pept. Section Abstract Doc Link 6138821 Disease Relevance 0.07 Pain Relevance 0.40
The data revealed significantly increased levels of prodynorphin mRNA expression in mice susceptible to ethanol withdrawal convulsions after withdrawal, with no corresponding increase in prodynorphin steady-state levels in mice resistant to ethanol withdrawal convulsions.
Positive_regulation (increased) of Gene_expression (expression) of prodynorphin mRNA associated with convulsion and withdrawal
17) Confidence 0.26 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871698 Disease Relevance 0.53 Pain Relevance 0.40
DMSO-primed GATA-4 and Nkx-2.5 gene expression was preceded by a marked increase in prodynorphin gene expression and dynorphin B synthesis and secretion.
Positive_regulation (increase) of Gene_expression (expression) of prodynorphin gene associated with dynorphin
18) Confidence 0.23 Published 2000 Journal Circ. Res. Section Abstract Doc Link 10926868 Disease Relevance 0 Pain Relevance 0.57
Cocaine administration increases activity at dopamine receptors, increases preprodynorphin (ppDyn) gene expression in the caudate-putamen (CPu), and activates the stress responsive hypothalamic-pituitary-adrenal (HPA) axis.
Positive_regulation (increases) of Gene_expression (expression) of increases preprodynorphin in CPu associated with stress, dopamine receptor and cocaine
19) Confidence 0.22 Published 2002 Journal Synapse Section Abstract Doc Link 12125043 Disease Relevance 0.25 Pain Relevance 0.50
These results support a specific role for MORs in acute cocaine effects on striatal ppEnk gene expression and fail to support critical roles for these receptors in acute cocaine's effects on either ppDyn gene expression or HPA activation.
Positive_regulation (activation) of Gene_expression (expression) of ppDyn associated with cocaine
20) Confidence 0.22 Published 2002 Journal Synapse Section Abstract Doc Link 12125043 Disease Relevance 0.07 Pain Relevance 0.81

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