INT30277

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Context Info
Confidence 0.52
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.90
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) aging (Ada)
cell adhesion (Ada) plasma membrane (Ada) lysosome (Ada)
Anatomy Link Frequency
sciatic nerve 1
Ada (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 36 100.00 Very High Very High Very High
Sciatic nerve 29 98.64 Very High Very High Very High
tetrodotoxin 2 94.16 High High
Neurotransmitter 3 90.72 High High
antagonist 4 75.04 Quite High
nMDA receptor 2 74.60 Quite High
Neuropeptide 1 73.88 Quite High
withdrawal 10 71.12 Quite High
Brush evoked pain 40 66.36 Quite High
cerebral cortex 1 54.32 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 102 93.36 High High
Neuropathic Pain 47 66.36 Quite High
Nociception 17 50.24 Quite High
Hyperalgesia 10 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 5 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both 1,3-dipropyl-8-cyclopentylxanthine and the adenosine-degrading enzyme adenosine deaminase produced an apparently irreversible depolarization of the membrane potential by about 20 mV.
Protein_catabolism (degrading) of adenosine deaminase associated with adenocard
1) Confidence 0.52 Published 1993 Journal Neuroscience Section Abstract Doc Link 8309525 Disease Relevance 0 Pain Relevance 0.42
The presence of low levels of adenosine in sciatic nerve extracts is consistent with its metabolism to AMP and/or with high adenosine deaminase activity causing degradation to inosine and other breakdown products.
Protein_catabolism (degradation) of adenosine deaminase in sciatic nerve associated with adenocard and sciatic nerve
2) Confidence 0.11 Published 2008 Journal Diabetes Section Body Doc Link PMC2551692 Disease Relevance 0.90 Pain Relevance 0.62
The effect of ATP was equipotent to that of its stable isostere alpha, beta-methylene ATP and resistant to degradation by adenosine deaminase, indicating interaction of ATP with purinergic-P2 receptors.
Protein_catabolism (degradation) of adenosine deaminase associated with adenocard
3) Confidence 0.03 Published 1985 Journal Gastroenterology Section Abstract Doc Link 2861138 Disease Relevance 0 Pain Relevance 0.38

General Comments

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