INT302794

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
lymphoid tissues 2
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 71.52 Quite High
Arthritis 64 55.92 Quite High
Inflammation 43 55.52 Quite High
metalloproteinase 1 10.60 Low Low
chemokine 2 5.96 Low Low
cytokine 15 5.48 Low Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 45 85.40 High High
Rheumatoid Arthritis 65 71.52 Quite High
Arthritis 62 55.92 Quite High
Necrosis 5 47.52 Quite Low
Cancer 12 47.16 Quite Low
INFLAMMATION 17 33.40 Quite Low
Carcinoma 1 29.76 Quite Low
Adhesions 1 6.36 Low Low
Death 3 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, inhibiting the formation of S1P either by targeting SphK, or by inhibiting the binding of S1P to S1PR1/S1PR2 is likely to result in a reduced egress of activated T-cell and B-cell from lymphoid tissues and presumably fewer activated lymphocytes making their way into the synovium.
Negative_regulation (inhibiting) of S1P Binding (formation) of in lymphoid tissues
1) Confidence 0.25 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.34 Pain Relevance 0.15

General Comments

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