INT3028

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Context Info
Confidence 0.58
First Reported 1976
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 76
Total Number 77
Disease Relevance 18.52
Pain Relevance 24.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
uterine 4
plasma 3
uterus 3
MCN 2
P19 1
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 74 100.00 Very High Very High Very High
antagonist 66 100.00 Very High Very High Very High
Dismenorea 61 100.00 Very High Very High Very High
Opioid 39 100.00 Very High Very High Very High
Analgesic 14 100.00 Very High Very High Very High
amygdala 10 100.00 Very High Very High Very High
Somatostatin 3 100.00 Very High Very High Very High
Morphine 40 99.98 Very High Very High Very High
Endogenous opioid 29 99.98 Very High Very High Very High
Neuropeptide 17 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 108 100.00 Very High Very High Very High
Dysmenorrhea 57 100.00 Very High Very High Very High
Aggression 3 100.00 Very High Very High Very High
Cancer 18 99.86 Very High Very High Very High
Pre-term Labor 36 99.70 Very High Very High Very High
INFLAMMATION 6 99.68 Very High Very High Very High
Targeted Disruption 22 99.52 Very High Very High Very High
Premature Birth 4 99.20 Very High Very High Very High
Sprains And Strains 9 99.14 Very High Very High Very High
Hypertension 10 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oxytocin is known to be inhibited by endogenous opioids at parturition, thus future research should consider the potential role of increased nociception at birth as a negative feedback to oxytocin release.
Negative_regulation (inhibited) of Oxytocin associated with nociception and endogenous opioid
1) Confidence 0.58 Published 1997 Journal Pain Section Abstract Doc Link 9272799 Disease Relevance 0.52 Pain Relevance 0.56
MATERIAL/METHODS: We searched MEDLINE, EMBASE, the Cochrane Controlled Trials Register and Science Citation Index using the following Medical Subject Headings and textwords: oxytocin (antagonists and inhibitors), atosiban, antocin, oxytocin antagonists, oxytocin receptor antagonists and oxytocin inhibitors.
Negative_regulation (inhibitors) of oxytocin
2) Confidence 0.58 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 12444392 Disease Relevance 0 Pain Relevance 0
RESULTS: Significant reduction in the mean oxytocin concentration was found in the patients who received morphine (-2.62 pmol/l/sample) but no change was found in the naloxone group (+0.57 pmol/l/sample) when compared with controls (+0.64 pmol/l/sample).
Negative_regulation (reduction) of oxytocin
3) Confidence 0.57 Published 1992 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1483291 Disease Relevance 0 Pain Relevance 0
Evidence of uterine hyperstimulation requiring temporary reduction of the oxytocin dose occurred in 19 and 20.2% of the patients in the external and internal tocography groups, respectively.
Negative_regulation (reduction) of oxytocin in external
4) Confidence 0.56 Published 1990 Journal Obstet Gynecol Section Abstract Doc Link 2196493 Disease Relevance 0.07 Pain Relevance 0.18
Furthermore, primiparous women who receive oxytocin have a reduced
                   likelihood of an unassisted vaginal delivery.44 The use of explicit criteria for admission in labour has been
                   associated with a significant reduction in use of oxytocin in labour.5 Secondary outcomes were interventions in
                   labour (artificial rupture of membranes, vaginal examination, continuous
                   electronic fetal monitoring, and use of analgesia), admission management (number
                   of admissions before labour, time spent in labour ward, and duration of active
                   labour), and labour outcomes (mode of delivery, intrapartum complications,
                   neonatal outcome, and unplanned out of hospital births).


Negative_regulation (reduction) of oxytocin associated with rupture and analgesia
5) Confidence 0.54 Published 2008 Journal BMJ : British Medical Journal Section Body Doc Link PMC2601030 Disease Relevance 0.10 Pain Relevance 0.09
Oxytocin receptor blockade: a new principle in the treatment of preterm labor?
Negative_regulation (blockade) of Oxytocin associated with pre-term labor
6) Confidence 0.53 Published 1989 Journal Am J Perinatol Section Title Doc Link 2540760 Disease Relevance 0.55 Pain Relevance 0.14
These preliminary findings support the concept that an increased concentration of uterine oxytocin receptors is an important etiologic factor in uncomplicated preterm labor and therefore oxytocin receptor blockade may be a therapeutic alternative for this condition.
Negative_regulation (blockade) of oxytocin in uterine associated with pre-term labor
7) Confidence 0.53 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540760 Disease Relevance 0.57 Pain Relevance 0.15
This difference may arise from changes in regulation in mouse pregnancy or because of the strain we used, C57BL/6, that lacks melatonin, a regulator of oxytocin rhythmicity [14].
Negative_regulation (regulator) of oxytocin associated with sprains and strains
8) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1976559 Disease Relevance 0.17 Pain Relevance 0.07
Oxytocin levels rose significantly during the nipple stimulation and short bursts of oxytocin were recorded during contractions.
Negative_regulation (rose) of Oxytocin in nipple
9) Confidence 0.43 Published 1989 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 2618602 Disease Relevance 0.18 Pain Relevance 0.09
MATERIAL/METHODS: We searched MEDLINE, EMBASE, the Cochrane Controlled Trials Register and Science Citation Index using the following Medical Subject Headings and textwords: oxytocin (antagonists and inhibitors), atosiban, antocin, oxytocin antagonists, oxytocin receptor antagonists and oxytocin inhibitors.
Negative_regulation (inhibitors) of oxytocin
10) Confidence 0.43 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 12444392 Disease Relevance 0 Pain Relevance 0
A competitive inhibitor of the action of oxytocin on the uterus, 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin, was studied for the first time in 13 patients with established, uncomplicated premature labour.
Negative_regulation (inhibitor) of oxytocin in uterus associated with pre-term labor
11) Confidence 0.42 Published 1987 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3322368 Disease Relevance 0.30 Pain Relevance 0.14
Oxytocin deficiency at delivery with epidural analgesia.
Negative_regulation (deficiency) of Oxytocin associated with epidural and analgesia
12) Confidence 0.42 Published 1983 Journal Br J Obstet Gynaecol Section Title Doc Link 6830729 Disease Relevance 0 Pain Relevance 0.45
Moreover the contraction of those smooth muscles by such spasmogens as acetylcholine, histamine serotonin, BaCl2 and oxytocin was inhibited by PZ-177 and the activity was almost the same with each spasmogen.
Negative_regulation (inhibited) of oxytocin in smooth muscles associated with serotonin
13) Confidence 0.42 Published 1976 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 986349 Disease Relevance 0.28 Pain Relevance 0.34
BACKGROUND: Oxytocin antagonists have been shown to inhibit uterine contractions and delay preterm delivery.
Negative_regulation (inhibit) of Oxytocin in uterine associated with premature birth, antagonist and dismenorea
14) Confidence 0.42 Published 2002 Journal Med. Sci. Monit. Section Abstract Doc Link 12444392 Disease Relevance 0.20 Pain Relevance 0.23
Morphine suppresses the oxytocin response in breast-feeding women.
Negative_regulation (suppresses) of oxytocin associated with morphine
15) Confidence 0.42 Published 1999 Journal Gynecol. Obstet. Invest. Section Title Doc Link 10394089 Disease Relevance 0 Pain Relevance 0.79
It was also associated with a reduced need for oxytocin (relative risk 0.52, 95% confidence interval 0.41 to 0.68) and reduced failure to achieve vaginal delivery within 24 hours (relative risk 0.36, 95% confidence interval 0.19 to 0.68).
Negative_regulation (reduced) of oxytocin
16) Confidence 0.42 Published 2001 Journal Cochrane Database Syst Rev Section Body Doc Link 11686970 Disease Relevance 0 Pain Relevance 0
Evidence for opioidergic inhibition of oxytocin release in periparturient mares.
Negative_regulation (inhibition) of oxytocin
17) Confidence 0.42 Published 1996 Journal Theriogenology Section Title Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.28
RESULTS: The incidence of instrumental delivery and Caesarean section and the need for oxytocin was reduced in the LD compared to HD group.
Negative_regulation (reduced) of oxytocin
18) Confidence 0.42 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9542554 Disease Relevance 0 Pain Relevance 0
It was also associated with a reduced need for oxytocin (relative risk 0.52, 95% confidence interval 0.41 to 0.68).
Negative_regulation (reduced) of oxytocin
19) Confidence 0.42 Published 2001 Journal Cochrane Database Syst Rev Section Body Doc Link 11279698 Disease Relevance 0 Pain Relevance 0
In conclusion, these data suggest that endogenous opioids suppress oxytocin secretion pre and post partum.
Negative_regulation (suppress) of oxytocin associated with endogenous opioid
20) Confidence 0.42 Published 1996 Journal Theriogenology Section Abstract Doc Link 16727907 Disease Relevance 0 Pain Relevance 0.36

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