INT302813

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.20
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 66 99.48 Very High Very High Very High
Osteoarthritis 109 97.80 Very High Very High Very High
cytokine 39 93.36 High High
Inflammatory response 10 84.00 Quite High
Inflammation 95 54.72 Quite High
Inflammatory mediators 6 32.56 Quite Low
agonist 3 14.36 Low Low
Arthritis 64 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 209 99.60 Very High Very High Very High
Rheumatoid Arthritis 66 99.48 Very High Very High Very High
Osteoarthritis 109 97.80 Very High Very High Very High
Apoptosis 56 96.12 Very High Very High Very High
Targeted Disruption 7 95.40 Very High Very High Very High
Cancer 161 94.08 High High
Body Weight 4 87.92 High High
Death 4 87.60 High High
Necrosis 5 84.84 Quite High
INFLAMMATION 78 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The highest adipokine concentration induced an early activation of STAT 1?
Positive_regulation (induced) of Positive_regulation (activation) of STAT
1) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.13 Pain Relevance 0.10
The level of STAT activation increased with the BMI, but the difference between both groups of patients did not reach statistical significance.


Positive_regulation (increased) of Positive_regulation (activation) of STAT associated with obesity
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.30 Pain Relevance 0.14
Interestingly, in the context of gp130 mediated Stat activation, Stat1 and Stat3 are capable of regulating each other [32,33].
Positive_regulation (mediated) of Positive_regulation (activation) of Stat
3) Confidence 0.05 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.29 Pain Relevance 0.15
-induced suppression of TRAIL-signaling beyond activation of STAT proteins in RA-FLS remains unknown, several more recent studies have addressed other aspects of apoptosis resistance in continuously proliferating cancer cells induced by INF-?
Positive_regulation (induced) of Positive_regulation (activation) of STAT associated with cancer, rheumatoid arthritis and apoptosis
4) Confidence 0.04 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.48 Pain Relevance 0.19

General Comments

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